Sanci Lena, Coffey Carolyn, Olsson Craig, Reid Sophie, Carlin John B, Patton George
Department of General Practice, University of Melbourne, 200 Berkeley St, Carlton, Victoria 3053, Australia.
Arch Pediatr Adolesc Med. 2008 Mar;162(3):261-7. doi: 10.1001/archpediatrics.2007.58.
To examine the relationship between childhood sexual abuse (CSA) before the age of 16 years and later onset of bulimia and anorexia nervosa symptoms in females.
A longitudinal cohort study of adolescents observed from August 1992 to March 2003. The cohort was defined in a 2-stage cluster sample using 44 Australian schools in Victoria.
Population based.
A total of 1936 persons participated at least once and survived to the age of 24 years, including 999 females. The mean (SD) age of females at the start of follow-up was 14.91 (0.39) years; and at completion, 24.03 (0.55) years. Main Exposure Self-reported CSA before the age of 16 years was ascertained retrospectively at the age of 24 years.
Incident Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition)-defined partial syndromes of anorexia and bulimia nervosa were identified between waves 4 (mean age, 16.3 years) and 6 (mean age, 17.4 years) using the Branched Eating Disorder Test.
The incidence of bulimic syndrome during adolescence was 2.5 (95% confidence interval, 0.80-8.0) times higher among those who reported 1 episode of CSA and 4.9 (95% confidence interval, 1.9-12.7) times higher among those who reported 2 or more episodes of CSA, compared with females reporting no episodes, adjusted for age and background factors. The association persisted after adjusting for possible confounders or mediators measured 6 months earlier, including psychiatric morbidity and dieting behavior. There was little evidence of an association between CSA and partial syndromes of incident anorexia nervosa.
Childhood sexual abuse seems to be a risk factor for the development of bulimic syndromes, not necessarily mediated by psychiatric morbidity or severe dieting.
探讨16岁之前的童年期性虐待(CSA)与女性之后出现的神经性贪食症和神经性厌食症症状之间的关系。
对1992年8月至2003年3月期间观察到的青少年进行的一项纵向队列研究。该队列采用两阶段整群抽样法,选取了维多利亚州的44所澳大利亚学校进行定义。
基于人群。
共有1936人至少参与过一次并存活至24岁,其中包括999名女性。随访开始时女性的平均(标准差)年龄为14.91(0.39)岁;随访结束时为24.03(0.55)岁。主要暴露因素 在24岁时通过回顾性调查确定16岁之前自我报告的CSA情况。
在第4波(平均年龄16.3岁)至第6波(平均年龄17.4岁)期间,使用分支饮食失调测试确定符合《精神疾病诊断与统计手册》(第四版)定义的神经性厌食症和神经性贪食症部分综合征。
与未报告有CSA事件的女性相比,在调整年龄和背景因素后,报告有1次CSA事件的女性在青春期出现贪食症综合征的发生率高2.5倍(95%置信区间,0.80 - 8.0),报告有2次或更多次CSA事件的女性高4.9倍(95%置信区间,1.9 - 12.7)。在调整了6个月前测量的可能的混杂因素或中介因素(包括精神疾病发病率和节食行为)后,这种关联仍然存在。几乎没有证据表明CSA与偶发性神经性厌食症部分综合征之间存在关联。
童年期性虐待似乎是贪食症综合征发生的一个危险因素,不一定由精神疾病发病率或严重节食介导。