[Studies on deletions on chromosome 13 and their transmission in patients with retinoblastoma].

We analyzed the G-banded high-resolution chromosomes of 10 patients with retinoblastoma and found 3 cases with 13q14.2 deletion. Their fathers showed similar but mosaic deletions. The proportions of abnormal cells were 10%, 14% and 21% in the fathers of cases 4, 8 and 10, respectively. The incidence and extent of deletion are discussed. The results suggest that the incidence of 13q14 deletion in retinoblastoma patients rose. The findings suggest that the three 13q14 deletion carriers who did not develop retinoblastoma transmitted the deletion to their children.