Diatloff-Zito C, Turleau C, Cabanis M O, Macieira-Coelho A, de Grouchy J
C R Seances Acad Sci III. 1983;297(8):431-4.
Skin fibroblasts from normal children and two children with a 13q14 deletion retinoblastoma (Rb) were submitted to fractionated doses of gamma radiations. Irradiation reduced the population doublings in normal fibroblasts and the decline was inversely related to the dose. An increase in population doublings was obtained with one of the Rb cell lines. Foci appeared in the irradiated culture of the other Rb donor. It is suggested that fibroblasts from patients with Rb are able to express some phenotypical properties of transformed cells, perhaps related to factors rendering them more susceptible to carcinogens.
对正常儿童以及两名患有13q14缺失视网膜母细胞瘤（Rb）的儿童的皮肤成纤维细胞进行分次剂量的γ射线照射。照射减少了正常成纤维细胞的群体倍增次数，且这种减少与剂量呈负相关。其中一个Rb细胞系的群体倍增次数增加。在另一名Rb供体的照射培养物中出现了集落。这表明Rb患者的成纤维细胞能够表达一些转化细胞的表型特性，这可能与使它们更易受致癌物影响的因素有关。
