Heeren Joanna H M, Croonen Anita M, Pijnenborg Johanna M A
Department of Obstetrics and Gynaecology, Tweesteden Hospital, Tilburg, The Netherlands.
Int J Gynecol Pathol. 2008 Apr;27(2):243-6. doi: 10.1097/PGP.0b013e3181569a0a.
Primary extranodal marginal zone B-cell lymphoma (EMZL) of the female genital tract is a clinical indolent disease. A 61-year-old woman presenting with vaginal prolapse underwent a vaginal hysterectomy and anterior colporrhaphy. Histological examination of the uterus revealed lymphocytic infiltration of the endometrium. The immunohistochemical profile was not in accordance with any known reactive lymphocytic proliferation. Additional polymerase chain reaction and fluorescence in situ hybridization established the diagnosis of EMZL. After staging workup, it was classified as Ann-Arbor stage 1E. Therefore, no adjuvant therapy was needed. Incidental finding of EMZL in the endometrium is exceptional. The asymptomatic presentation is according to the indolent character of extranodal marginal zone lymphoma.
女性生殖道原发性结外边缘区B细胞淋巴瘤（EMZL）是一种临床惰性疾病。一名61岁因阴道脱垂就诊的女性接受了阴道子宫切除术和阴道前壁修补术。子宫组织学检查显示子宫内膜有淋巴细胞浸润。免疫组化结果不符合任何已知的反应性淋巴细胞增殖。进一步的聚合酶链反应和荧光原位杂交确诊为EMZL。分期检查后，其被归类为Ann-Arbor 1E期。因此，无需辅助治疗。子宫内膜偶然发现EMZL实属罕见。无症状表现符合结外边缘区淋巴瘤的惰性特征。
