Department of Internal Medicine, Faculty of Medicine, Celal Bayar University,45020 Manisa, Turkey.
PPAR Res. 2007;2007:39654. doi: 10.1155/2007/39654.
Peroxisome proliferator-activated receptors (PPARs) are key regulators in various age-associated pathophysiological processes related to energy metabolism and oxidative stress. A progressive rise of oxidative stress and related inflammatory reaction appears the hallmarks of the aging process and many age-related diseases. PPARs are important redox-sensitive transcription factors and their dyregulated activations seem to be major culprits for these pathological processes. Drugs targeting PPARs activity are already in widespread clinical use; however, based on these concepts, this review highlights the understanding of the role of PPARs in aging and indicates the necessary particular attention for the potential therapeutic uses of current PPAR agonists in age-associated diseases.
过氧化物酶体增殖物激活受体 (PPARs) 是与能量代谢和氧化应激相关的各种与年龄相关的病理生理过程中的关键调节因子。氧化应激的逐渐增加和相关的炎症反应似乎是衰老过程和许多与年龄相关的疾病的特征。PPARs 是重要的氧化还原敏感转录因子，其活性失调似乎是这些病理过程的主要罪魁祸首。针对 PPAR 活性的药物已广泛应用于临床；然而，基于这些概念，本综述强调了 PPAR 在衰老中的作用，并指出了当前 PPAR 激动剂在与年龄相关的疾病中的潜在治疗用途所需的特别关注。
