Kengen R A, Meijer S, Beekhuis H, Piers D A
Department of Nuclear Medicine, University Hospital Groningen, The Netherlands.
J Nucl Med. 1991 Sep;32(9):1709-12.
Although the renal clearance of 99mTc-MAG3 is about 60% of the 131I-hippurate clearance, 99mTc-MAG3 clearance may be useful to estimate ERPF. In one study, however, proteinuria seemed to influence the MAG3/hippurate clearance ratio. In order to establish whether proteinuria or serum albumin level has influence on this ratio, a comparison was made between 99mTc-MAG3 clearance and 131I-hippurate clearance in 14 patients. There was a good linear correlation between MAG3 and hippurate clearance, although the standard error of estimate of ERPF from MAG3 was relatively large, which remained unexplained. No correlation was found between proteinuria and MAG3/hippurate clearance ratio nor between serum albumin level, GFR, FF, ERPF and the MAG3/hippurate clearance ratio. We therefore conclude that there is no correlation between proteinuria and albumin level and the MAG3/hippurate ratio. A reasonable estimation of ERPF with MAG3 can be made in patients with proteinuria and lowered serum albumin levels although the estimation may be less accurate.
尽管99mTc-MAG3的肾清除率约为131I-马尿酸盐清除率的60%，但99mTc-MAG3清除率可能有助于估计有效肾血浆流量（ERPF）。然而，在一项研究中，蛋白尿似乎会影响MAG3/马尿酸盐清除率。为了确定蛋白尿或血清白蛋白水平是否会影响该比率，对14例患者的99mTc-MAG3清除率和131I-马尿酸盐清除率进行了比较。MAG3和马尿酸盐清除率之间存在良好的线性相关性，尽管根据MAG3估计ERPF的标准误差相对较大，原因尚不明。未发现蛋白尿与MAG3/马尿酸盐清除率之间存在相关性，血清白蛋白水平、肾小球滤过率（GFR）、滤过分数（FF）、ERPF与MAG3/马尿酸盐清除率之间也无相关性。因此，我们得出结论，蛋白尿和白蛋白水平与MAG3/马尿酸盐比率之间不存在相关性。尽管估计可能不太准确，但对于蛋白尿患者和血清白蛋白水平降低的患者，可以用MAG3对ERPF进行合理估计。
