在人单核细胞感染弗朗西斯菌期间，γ干扰素增强白细胞介素-23的产生。
IFNgamma enhances IL-23 production during Francisella infection of human monocytes.
作者信息
Butchar Jonathan P, Parsa Kishore V L, Marsh Clay B, Tridandapani Susheela
机构信息
Division of Pulmonary and Critical Care, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA.
出版信息
FEBS Lett. 2008 Apr 2;582(7):1044-8. doi: 10.1016/j.febslet.2008.02.058. Epub 2008 Mar 3.
Abstract
We previously demonstrated that monocytes produce IL-23 during Francisella infection, and that IL-23 induces IFNgamma from NK cells. Here, we demonstrate that IFNgamma-priming of monocytes enhances IL-23 production during Francisella infection. This effect was seen on the IL12/23 p40 subunit. Induction of IL-12/23 p40 is reported to be enhanced by IRF-1 and IRF-8. Consistently, microarray analysis of IFNgamma-treated monocytes revealed a significant induction of the IRFs. Interestingly, IFNgamma-primed monocytes produced IL-12 p70, a more potent inducer of IFNgamma than IL-23. We propose that there exists an amplification loop between monocyte IL-23 and NK/T cell IFNgamma that leads to IL-12 p70 production.
摘要
我们之前证明，在弗朗西斯菌感染期间单核细胞会产生白细胞介素-23（IL-23），且IL-23可诱导自然杀伤细胞（NK细胞）产生γ干扰素（IFNγ）。在此，我们证明单核细胞经IFNγ预处理后，在弗朗西斯菌感染期间会增强IL-23的产生。这种效应在白细胞介素12/23 p40亚基上可见。据报道，干扰素调节因子1（IRF-1）和干扰素调节因子8（IRF-8）可增强IL-12/23 p40的诱导。与此一致，对经IFNγ处理的单核细胞进行的微阵列分析显示IRFs有显著诱导。有趣的是，经IFNγ预处理的单核细胞产生了白细胞介素12 p70，它是比IL-23更强的IFNγ诱导剂。我们提出，在单核细胞IL-23与NK/T细胞IFNγ之间存在一个放大环路，该环路导致IL-12 p70的产生。
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2
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J Leukoc Biol. 2006 Oct;80(4):766-73. doi: 10.1189/jlb.0406294. Epub 2006 Aug 8.
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