Kemp-Harper Barbara, Feil Robert
Department of Pharmacology and Centre for Vascular Health, Monash University, Clayton, Victoria, Australia.
Sci Signal. 2008 Mar 4;1(9):pe12. doi: 10.1126/stke.19pe12.
The second messenger cyclic guanosine 3',5'-monophosphate (cGMP) controls many cellular functions ranging from growth to contractility. Generated from guanylyl cyclases in response to natriuretic peptides or nitric oxide, cGMP transduces its effects through a number of cGMP effectors, including cGMP-regulated phosphodiesterases and protein kinases. Drugs that modulate cGMP levels are emerging as promising therapies, particularly for cardiovascular disorders. This report summarizes new data on the molecular mechanisms, (patho)physiological relevance, and therapeutic potential of the cGMP signaling system that were presented at the 3rd cGMP meeting held in June 2007 in Dresden, Germany.
第二信使环鸟苷酸3',5'-单磷酸（cGMP）控制着从生长到收缩性等多种细胞功能。cGMP由鸟苷酸环化酶响应利钠肽或一氧化氮生成，通过多种cGMP效应器转导其作用，包括cGMP调节的磷酸二酯酶和蛋白激酶。调节cGMP水平的药物正成为有前景的治疗方法，尤其是用于心血管疾病。本报告总结了在2007年6月于德国德累斯顿举行的第三届cGMP会议上提出的关于cGMP信号系统的分子机制、（病理）生理相关性和治疗潜力的新数据。
