Tominaga S, Jenkins N A, Gilbert D J, Copeland N G, Tetsuka T
Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.
Biochim Biophys Acta. 1991 Aug 27;1090(1):1-8. doi: 10.1016/0167-4781(91)90029-l.
The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5' flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.
基于与小鼠ST2互补DNA序列的同源性，分离出小鼠ST2基因的基因组位点，并确定了其完整的核苷酸序列。该位点由八个外显子和七个内含子组成，大小约为9千碱基对。在5'侧翼区域存在两个Sp1结合位点。仅在生长刺激的BALB/c - 3T3细胞中表达的小鼠ST2基因被定位到小鼠1号染色体上，与白细胞介素1受体1型位点紧密连锁。
