Tominaga S
Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
FEBS Lett. 1989 Dec 4;258(2):301-4. doi: 10.1016/0014-5793(89)81679-5.
A cDNA clone, which represents a species of mRNA that is expressed in growth-stimulated BALB/c-3T3 cells but not in resting cells, was found to encode a protein remarkably similar in sequence to the members of the immunoglobulin superfamily, especially to the extracellular portion of the mouse interleukin 1 receptor. The immunoglobulin superfamily is believed to be involved in cell adhesion and cell-to-cell interaction. The evidence that a member of this family is induced in the course of the initiation of cell proliferation is intriguing.
发现一个cDNA克隆，它代表一种在生长刺激的BALB/c - 3T3细胞中表达而在静止细胞中不表达的mRNA物种，该克隆编码的蛋白质在序列上与免疫球蛋白超家族成员非常相似，尤其与小鼠白细胞介素1受体的细胞外部分相似。免疫球蛋白超家族被认为参与细胞黏附和细胞间相互作用。该家族的一个成员在细胞增殖起始过程中被诱导，这一证据很有趣。
