Dzupa V, Dzupová O, Bendová E, Záhorka J, Richtr V, Bartoska R, Skála-Rosenbaum J, Zídka M
LF Univerzity Karlovy a FN Královské Vinohrady, Praha.
Klin Mikrobiol Infekc Lek. 2007 Dec;13(6):242-7.
Infection is considered one of the most serious complications of the surgical treatment of musculoskeletal injuries. The aim of the study was to evaluate known risk factors and etiological agents of infectious complications in patients surgically treated for musculoskeletal injuries within 6 years.
In a group of 5 234 patients followed in 2000-2005 the early or delayed infectious complication developed in 65 patients (26 women, 39 men, age 22-83 years). In every patient with infectious complication the important risk factors related to personal history, type of the injury, surgery and other treatment were recorded and microbiological culture results were collected.
In 60 patients (92.3%) at least one of the following risk factors was registered: diabetes mellitus, age above 75 years, abuse of alcohol and drugs, distant infectious focus or severe skin disease at the time of surgery, polytrauma requiring long-termed stay in intensive care unit, extensive soft tissue injury associated with closed or opened fracture. In 27 patients (41.5%) grampositive cocci and in 17 patients (26.2%) gramnegative bacteria were isolated, in 12 patients (18.5%) mixed bacterial flora was identified and 9 patients (13.8%) had negative cultures. The most severe findings from microbiological view occurred in patients with extensive soft tissue injury associated with fracture, diabetes or long-termed stay in intensive care unit.
The infectious complications after the surgical treatment of musculoskeletal injuries occurred predominantly in patients with risk factors. The extensive soft tissue injury associated with fracture, diabetes and long-termed stay of the polytrauma patient in intensive care unit were identified as the most frequent risk factors. The patients of these risk groups also presented with the most serious microbiological findings.
感染被认为是肌肉骨骼损伤外科治疗最严重的并发症之一。本研究的目的是评估6年内接受肌肉骨骼损伤外科治疗患者感染并发症的已知危险因素和病原体。
在2000年至2005年随访的5234例患者中,65例(26例女性,39例男性,年龄22 - 83岁)发生了早期或延迟性感染并发症。对每例感染并发症患者记录与个人病史、损伤类型、手术及其他治疗相关的重要危险因素,并收集微生物培养结果。
60例患者(92.3%)记录到至少以下危险因素之一:糖尿病、75岁以上、酗酒和药物滥用、手术时远处感染灶或严重皮肤病、需要长期入住重症监护病房的多发伤、与闭合或开放性骨折相关的广泛软组织损伤。27例患者(41.5%)分离出革兰氏阳性球菌,17例患者(26.2%)分离出革兰氏阴性菌,12例患者(18.5%)鉴定为混合菌群,9例患者(13.8%)培养结果为阴性。从微生物学角度看,最严重的结果发生在伴有骨折的广泛软组织损伤、糖尿病或长期入住重症监护病房的患者中。
肌肉骨骼损伤外科治疗后的感染并发症主要发生在有危险因素的患者中。与骨折相关的广泛软组织损伤、糖尿病以及多发伤患者在重症监护病房的长期停留被确定为最常见的危险因素。这些风险组的患者也呈现出最严重的微生物学结果。