Kauppila Tiina J, Arvola Ville, Haapala Markus, Pól Jaroslav, Aalberg Laura, Saarela Ville, Franssila Sami, Kotiaho Tapio, Kostiainen Risto
Division of Pharmaceutical Chemistry, Faculty of Pharmacy, P.O. Box 56, FI-00014 University of Helsinki, Finland.
Rapid Commun Mass Spectrom. 2008 Apr;22(7):979-85. doi: 10.1002/rcm.3461.
The feasibility of desorption atmospheric pressure photoionization (DAPPI) in the direct analysis of illicit drugs was demonstrated by the analysis of confiscated drug samples of various forms such as tablets, blotter paper, and plant resin and bloom. 3,4-Methylenedioxymethamphetamine (MDMA), amphetamine, phenazepam, and buprenorphine were detected from the analyzed tablets, lysergic acid diethylamide (LSD) and bromobenzodifuranylisopropylamine (bromo-Dragonfly, ABDF) from blotter paper, and Delta(9)-tetrahydrocannabinol (THC) and cannabinol from Cannabis Sativa bloom and resin. The amphetamines, phenazepam and ABDF showed protonated molecules independent of the solvent used, whereas buprenorphine, LSD and the cannabinoids showed molecular ions with toluene and protonated molecules with acetone as the solvent.
通过对片剂、吸墨纸、植物树脂和花等各种形式的没收毒品样本进行分析，证明了解吸常压光电离（DAPPI）在非法药物直接分析中的可行性。从分析的片剂中检测到3,4-亚甲基二氧甲基苯丙胺（摇头丸）、苯丙胺、芬那西泮和丁丙诺啡，从吸墨纸中检测到麦角酸二乙酰胺（LSD）和溴苯二呋喃异丙胺（溴蜻蜓，ABDF），从大麻的花和树脂中检测到Δ⁹-四氢大麻酚（THC）和大麻酚。苯丙胺类、芬那西泮和ABDF显示出与所用溶剂无关的质子化分子，而丁丙诺啡、LSD和大麻素类则显示出以甲苯为溶剂的分子离子和以丙酮为溶剂的质子化分子。
