Slocombe J Owen D, Coté John F, de Gannes Rolph V G
Ontario Veterinary College, Department of Pathobiology, University of Guelph.
Can Vet J. 2008 Jan;49(1):56-60.
Three clinical trials with fecal egg count reduction tests and coproculture were conducted on 2 standardbred farms in Ontario. On Farm A, the treatment groups were mebendazole and ivermectin in trial 1, and fenbendazole and moxidectin in another. On Farm B, treatment groups were mebendazole and ivermectin. All horses treated with mebendazole or fenbendazole were subsequently treated with ivermectin or moxidectin. Strongyle eggs/g feces were estimated pre- and post-treatment using the Cornell-McMaster dilution and Cornell-Wisconsin centrifugal flotation techniques. After treatment, there was no change in the arithmetic mean eggs/g feces for horses given mebendazole, and a reduction of only 49.1% for those given fenbendazole. All horses receiving ivermectin or moxidectin had their egg counts reduced to 0. Only cyathostomes were found on culture. On both farms the benzimidazole resistant strains appeared to have persisted for at least 10 years. Development of and monitoring for anthelmintic resistance are briefly discussed.
在安大略省的2个标准赛马场进行了3项粪便虫卵计数减少试验和粪便培养试验。在农场A，试验1中的治疗组为甲苯咪唑和伊维菌素，另一试验中的治疗组为芬苯达唑和莫西菌素。在农场B，治疗组为甲苯咪唑和伊维菌素。所有接受甲苯咪唑或芬苯达唑治疗的马匹随后都接受了伊维菌素或莫西菌素治疗。使用康奈尔-麦克马斯特稀释法和康奈尔-威斯康星离心浮选技术在治疗前后估计每克粪便中的圆线虫卵数量。治疗后，接受甲苯咪唑治疗的马匹每克粪便中虫卵的算术平均值没有变化，接受芬苯达唑治疗的马匹仅减少了49.1%。所有接受伊维菌素或莫西菌素治疗的马匹的虫卵计数都降至0。培养时仅发现了杯状线虫。在两个农场，苯并咪唑抗性菌株似乎已经持续存在了至少10年。简要讨论了抗蠕虫药耐药性的产生和监测。
