肿瘤免疫中的NKT细胞：相互对立的亚群定义了一条新的免疫调节轴。

NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis.

作者信息

Berzofsky Jay A, Terabe Masaki

机构信息

Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1578, USA.

出版信息

J Immunol. 2008 Mar 15;180(6):3627-35. doi: 10.4049/jimmunol.180.6.3627.

DOI:10.4049/jimmunol.180.6.3627

PMID:18322166

Abstract

NKT cells are true Ag-specific T cells that also have innate properties and form a bridge between the innate and adaptive immune systems. Distinct NKT cell subsets play positive and negative regulatory roles and define a new immunoregulatory axis with broad implications for tumor immunity and other immunological and disease settings.

摘要

自然杀伤T细胞（NKT细胞）是真正的抗原特异性T细胞，它们还具有先天性特性，并在先天性免疫系统和适应性免疫系统之间架起了一座桥梁。不同的NKT细胞亚群发挥着正向和负向调节作用，并定义了一个新的免疫调节轴，这对肿瘤免疫以及其他免疫和疾病情况具有广泛影响。