Zhao Hui, Li Ming-hui, Xie Yao, Du Shao-cai, Xu Dao-zhen
Clinical Laboratory, Beijing Ditan Hospital, Beijing 100011, China.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Dec;21(4):355-7.
To investigate the relationship of hepatitis C virus (HCV) serotype with genotype.
The serotypes of HCV in the serum of 104 patients with chronic hepatitis C from 14 cities in China for which HCV genotypes were available, were determined by ELISA using Murex HCV Serotyping 1-6 Assay.
The serotypes of 86 (82.69 percent) of the 104 serum specimens were determined, and HCV serotypes were determined for 91 strains. Overall the concordance between hepatitis C virus serotype and genotype was 62.1 percent, and the concordance of serotype, with genotypes 1, 2 and 3 were 69.4 percent, 51.2 percent and 70.0 percent, respectively. The false-negative rate and concordance of genotype 2b was lower (54.5 percent).
The specificity of HCV serotyping was affected by HCV strains' genotype and sometimes HCV serotype was not in concordance with genotype.
