Freeman Hugh-James
Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada.
World J Gastroenterol. 2008 Mar 7;14(9):1318-20. doi: 10.3748/wjg.14.1318.
Fundic gland polyps are now commonly recognized during endoscopy. These polyps are benign, often multiple and usually detected in the gastric body and fundus. In the past, these polyps were sometimes associated with familial adenomatous polyposis. In recent years, it has become evident that increasing numbers of these polyps are being detected during endoscopic studies, particularly in patients treated with proton pump inhibitors for prolonged periods. In some, dysplastic changes in these polyps have also been reported. Recent studies have suggested that there may be no increase in risk of colon cancer with long-term proton pump inhibitor therapy. While temporarily reassuring, ongoing vigilance, particularly in those genetically predisposed to colon cancer, is still warranted.
胃底腺息肉现在在内镜检查中很常见。这些息肉是良性的，通常为多发，且常在胃体和胃底被发现。过去，这些息肉有时与家族性腺瘤性息肉病有关。近年来，越来越明显的是，在内镜检查中发现的这类息肉数量不断增加，尤其是在长期接受质子泵抑制剂治疗的患者中。在一些病例中，也有关于这些息肉发育异常变化的报道。最近的研究表明，长期使用质子泵抑制剂治疗可能不会增加患结肠癌的风险。虽然这暂时让人安心，但仍需持续警惕，尤其是对那些有结肠癌遗传易感性的人。
