[家蚕蚕沙中的生物碱成分]
[Alkaloid constituents from silkworm dropping of Bombyx mori].
作者信息
Zhou Guang-xiong, Ruan Jie-wu, Huang Mei-yan, Ye Wen-cai, He Ye-wei
机构信息
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
出版信息
Zhong Yao Cai. 2007 Nov;30(11):1384-5.
OBJECTIVE
To extract and isolate chemical constituents from the total alkaloids of silkworm dropping (Can Sha) of Bombyx mori L.
METHODS
Chemical constituents were isolated by column chromatography with macroporous adsorbent resin, ion-exchange resin and sephadex LH 20. The structures of the isolated compounds were determined by spectral means.
RESULTS
Three compounds were isolated and identified as 1-deoxynojirimycin (1) , fagomine (2) , and 3-epifagomine (3) on the basis of their 1H-NMR, 13C-NMR spectra and ESIMS data.
CONCLUSION
Compounds 1-3 are isolated and identified from Can Sha for the first time.
目的
从家蚕（Bombyx mori L.）蚕沙的总生物碱中提取并分离化学成分。
方法
采用大孔吸附树脂、离子交换树脂和葡聚糖凝胶LH 20柱色谱法分离化学成分。通过光谱手段确定分离得到化合物的结构。
结果
根据1H-NMR、13C-NMR光谱和电喷雾电离质谱（ESIMS）数据，分离并鉴定出3个化合物，分别为1-脱氧野尻霉素（1）、荞麦碱（2）和3-表荞麦碱（3）。
结论
化合物1-3首次从蚕沙中分离得到并鉴定。
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