Chen Jing, Cao Hong-xin, Yang Hua-sheng
Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Zhong Yao Cai. 2007 Nov;30(11):1411-3.
To observe the effects of Qiangxin Capsule on myocardial apoptosis in chronic heart failure rats.
The model was established by injecting ADR in intraperitoneal of Wistar rat. The models were devided into three groups those were prvention group with Chinese medicine, treatment group with Chinese medicine and control group with medicine. Cardiac myocyte apoptosis were detected by terminal deoxynucleotidyl transferaseediated dUTP nick-end labeling (TUNEL), Fas and cardiac expression level of Bcl-2 were detected by immunohistochemistry.
Qiangxin capsule could inhibit myocardial apoptosis and Fas protein expression on chronic heart failure rat obviously , and improve Bcl-2 protein expression.
Qianxin capsule can inhibit myocardial apoptosis and control Fas/Bcl-2 obviously. It may be one of its effects in delaying chronic heart failure.
观察强心胶囊对慢性心力衰竭大鼠心肌细胞凋亡的影响。
采用腹腔注射阿霉素法建立Wistar大鼠慢性心力衰竭模型，将造模成功大鼠分为中药预防组、中药治疗组和西药对照组。采用脱氧核糖核苷酸末端转移酶介导的缺口末端标记法（TUNEL）检测心肌细胞凋亡情况，免疫组织化学法检测Fas及Bcl-2蛋白表达水平。
强心胶囊可明显抑制慢性心力衰竭大鼠心肌细胞凋亡及Fas蛋白表达，提高Bcl-2蛋白表达。
强心胶囊可明显抑制心肌细胞凋亡，调控Fas/Bcl-2，这可能是其延缓慢性心力衰竭的作用机制之一。
