Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
Department of Clinical Biochemistry, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
J Cell Mol Med. 2018 Dec;22(12):6401-6404. doi: 10.1111/jcmm.13939. Epub 2018 Oct 15.
Oesophageal adenocarcinoma is one of the most fatal tumours to affect the digestive tract and is the eighth most common malignancy worldwide. Gastro-oesophageal reflux has an important role in the incidence of adenocarcinoma of the oesophagus. Gastro-oesophageal reflux disease (GERD) is a multifactorial, acid-peptic disorder that results from the reflux of noxious material from the stomach into the oesophagus. The refluxed material causes the occurrence of oesophageal inflammation which creates a condition that is called reflux oesophagitis. The prevalence of this disease has increased dramatically in recent decades, mostly in the western world, where it affects about 10% to 30% of the population. The aetiology of oesophageal mucosal damage is complicated. Many inflammatory mediators are produced within the gastrointestinal (GI) tract, but their contributions in pathophysiology and disease pathogenesis have not been well investigated. Despite the protective barrier provided by the oesophageal mucosa, refluxed materials can cause oxidative injury and in?ammatory responses that involve the epithelium and immune cells. The analysing cellular events in gastro- oesophageal reflux disease and physiological responses to such conditions are important and necessary for a better grasp of the pathogenesis of GERD and the expansion of new treatments. Therefore, we want to discuss some of the important and key factors of GERD disease in this article.
食管腺癌是最致命的消化道肿瘤之一，也是全球第八大常见恶性肿瘤。胃食管反流在食管腺癌的发生中起着重要作用。胃食管反流病（GERD）是一种多因素的、酸相关的疾病，是由于胃内有害物质反流进入食管引起的。反流物引起食管炎症，导致反流性食管炎。近年来，这种疾病在西方世界的发病率显著上升，在那里，大约有 10%到 30%的人口受到影响。食管黏膜损伤的病因很复杂。胃肠道（GI）中产生了许多炎症介质，但它们在病理生理学和疾病发病机制中的作用尚未得到很好的研究。尽管食管黏膜提供了保护屏障，但反流物仍可引起氧化损伤和涉及上皮和免疫细胞的炎症反应。分析胃食管反流病中的细胞事件和对这些情况的生理反应对于更好地理解 GERD 的发病机制和扩展新的治疗方法非常重要和必要。因此，我们希望在本文中讨论一些 GERD 疾病的重要和关键因素。
