Souteyrand P, Roger H, Ferrier M C, D'Incan M
Service de Dermatologie-Vénéréologie, Hôtel-Dieu, Clermont-Ferrand.
Rev Fr Gynecol Obstet. 1991 Jun;86(6):455-7.
The changes in the immune system during the ageing process have been described in numerous publications, which are sometimes contradictory. The study of cell mediated immunity and of hormonal immunity provide only a partial reflection of the smooth working of the cutaneous immune system, which is dependent on fragile cell interactions between T lymphocytes, cells of Langerhans and keratinocytes, which involves numerous soluble mediators. Three possible mechanisms leading to or contributing to the decline in immune function with age should be considered: a modification of the distribution of lymphocyte subpopulations (the T helper lymphocytes and T-suppressing lymphocytes are affected by age in particular), changes in the mechanisms of suppression and changes in the maturation of B and T lymphocytes.
衰老过程中免疫系统的变化已在众多出版物中有所描述，这些描述有时相互矛盾。对细胞介导免疫和激素免疫的研究仅部分反映了皮肤免疫系统的正常运作，而皮肤免疫系统依赖于T淋巴细胞、朗格汉斯细胞和角质形成细胞之间脆弱的细胞相互作用，这涉及众多可溶性介质。应考虑导致或促成免疫功能随年龄下降的三种可能机制：淋巴细胞亚群分布的改变（特别是辅助性T淋巴细胞和抑制性T淋巴细胞受年龄影响）、抑制机制的变化以及B淋巴细胞和T淋巴细胞成熟的变化。
