Babaeva A G
Ontogenez. 1989 Sep-Oct;20(5):453-60.
The published and author's data concerning changes in the immune system during regeneration of various organs are summarized. During the first few hours after partial removal of organs possessing high regeneration capacity, lymphocytes stimulate proliferation of nonlymphoid cells of an organ identical to the operated one; the production of antibodies against thymus-dependent antigen also increases. At the following stages of regeneration, the lymphocytes suppress the cell proliferation and decrease the antigen production. The level of these changes correlates with the level of post operational deficiency of the organ being maximal after total removal of the organ. The functional properties of splenocytes at different stages of regeneration suggest that the high T-helper and T-suppressor activities correlate with stimulation and suppression of non-lymphoid cells proliferation respectively. Culture medium supernatant after cultivation of these lymphocytes also changes the proliferation of hepatocytes. The author considers the impairment of natural immune tolerance caused by deficiency of organ auto-antigens that normally suppress lymphocyte proliferation to be the cause of the changes in lymphocyte activity.
总结了已发表的以及作者本人关于不同器官再生过程中免疫系统变化的数据。在部分切除具有高再生能力的器官后的最初几个小时内，淋巴细胞刺激与手术器官相同的器官中非淋巴细胞的增殖；针对胸腺依赖性抗原的抗体产生也会增加。在再生的后续阶段，淋巴细胞会抑制细胞增殖并减少抗原产生。这些变化的程度与器官切除后器官功能缺陷的程度相关，在器官完全切除后该缺陷程度最大。再生不同阶段脾细胞的功能特性表明，高T辅助细胞和T抑制细胞活性分别与非淋巴细胞增殖的刺激和抑制相关。这些淋巴细胞培养后的培养基上清液也会改变肝细胞的增殖。作者认为，正常情况下抑制淋巴细胞增殖的器官自身抗原缺乏导致自然免疫耐受受损，是淋巴细胞活性变化的原因。
