Tikhonravov Dmitry, Neuvonen Tuomas, Pertovaara Antti, Savioja Kati, Ruusuvirta Timo, Näätänen Risto, Carlson Synnöve
Neuroscience Unit, Institute of Biomedicine/Physiology, University of Helsinki, Finland; Helsinki Brain Research Center, Finland.
Brain Res. 2008 Apr 8;1203:97-102. doi: 10.1016/j.brainres.2008.02.006. Epub 2008 Feb 13.
In the human brain, auditory sensory memory has been extensively studied using a well-defined component of event-related potential named the mismatch negativity (MMN). The MMN is generated in the auditory and frontal cortices in response to deviant stimuli. In monkeys, cortical N-methyl-d-aspartate (NMDA) receptors have a central role in the generation of the MMN. MMN-like responses have also been recorded in other animals, including rats. The present study aimed at determining whether the MMN-like response in rats depends on an intact NMDA-receptor system. We recorded auditory evoked responses during an oddball paradigm epidurally in anesthetized rats that had received intraperitoneal injections of saline or an NMDA-receptor antagonist MK-801. An MMN-like response was recorded in the oddball paradigm in saline-treated rats. Further, this response was dose-dependently blocked by MK-801. These results suggest that the MMN-like response in rats depends on an intact NMDA-receptor system.
在人类大脑中，听觉感觉记忆已通过事件相关电位的一个明确定义的成分——失配负波（MMN）进行了广泛研究。MMN是在听觉和额叶皮质中由异常刺激诱发产生的。在猴子中，皮质N-甲基-D-天冬氨酸（NMDA）受体在MMN的产生中起核心作用。在包括大鼠在内的其他动物中也记录到了类似MMN的反应。本研究旨在确定大鼠中类似MMN的反应是否依赖于完整的NMDA受体系统。我们在接受腹腔注射生理盐水或NMDA受体拮抗剂MK-801的麻醉大鼠硬膜外，在奇偶数范式期间记录听觉诱发反应。在生理盐水处理的大鼠的奇偶数范式中记录到了类似MMN的反应。此外，该反应被MK-801剂量依赖性地阻断。这些结果表明，大鼠中类似MMN的反应依赖于完整的NMDA受体系统。
