大鼠大脑功能的扁平化皮质图谱：一种用于数据采样、分析和显示的感兴趣区域方法。
Flattened cortical maps of cerebral function in the rat: a region-of-interest approach to data sampling, analysis and display.
作者信息
Holschneider D P, Scremin O U, Chialvo D R, Kay B P, Maarek J-M I
机构信息
Department of Psychiatry and the Behavioral Sciences, University of Southern California School of Medicine, Los Angeles, CA 90033, USA.
出版信息
Neurosci Lett. 2008 Mar 28;434(2):179-84. doi: 10.1016/j.neulet.2008.01.061. Epub 2008 Feb 2.
We describe a method for the measurement, analysis and display of cerebral cortical data obtained from coronal brain sections of the adult rat. In this method, regions-of-interest (ROI) are selected in the cortical mantle in a semiautomated fashion using a radial grid overlay, spaced in 15 degrees intervals from the midline. ROI measurements of intensity are mapped on a flattened two-dimensional surface. Topographic maps of statistical significance at each ROI allow for the rapid viewing of group differences. Cortical z-scores are displayed with the boundaries of brain regions defined according to a standard atlas of the rat brain. This method and accompanying software implementation (Matlab, Labview) allow for compact data display in a variety of autoradiographic and histologic studies of the structure and function of the rat brain.
我们描述了一种用于测量、分析和显示从成年大鼠冠状脑切片获得的大脑皮质数据的方法。在该方法中，使用从脑中线起以15度间隔排列的径向网格叠加，以半自动方式在皮质套中选择感兴趣区域（ROI）。强度的ROI测量值映射在一个扁平的二维表面上。每个ROI处具有统计学意义的地形图允许快速查看组间差异。皮质z分数与根据大鼠脑标准图谱定义的脑区边界一起显示。这种方法及配套的软件实现（Matlab、Labview）允许在大鼠脑结构和功能的各种放射自显影和组织学研究中进行紧凑的数据显示。
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