Negley Candice, Katbamna Bharti, Crumpton Teresa, Lawson Gary D
Department of Speech Pathology and Audiology, Western Michigan University, 1903 West Michigan Avenue, Kalamazoo, MI 49008-5355, USA.
J Am Acad Audiol. 2007 Sep;18(8):665-74. doi: 10.3766/jaaa.18.8.4.
This study measured distortion product otoacoustic emissions (DPOAEs) and DPOAE input/output (I/O) curves to assess the effects of smoking on cochlear function. Twenty-four healthy adults, 12 smokers and 12 nonsmokers in the 20-30 years age range were selected based on self-reported histories of five to eight years of smoking or no smoking, respectively. All subjects received tympanometric screening to rule out middle ear pathology. Conventional (0.25-8 kHz) and ultra high frequency (UHF; 10-20 kHz) audiometry showed normal or age-appropriate thresholds across both groups. DPOAE results showed small, but significant, decline in DPOAE levels without concomitant changes in noise floors in smokers as compared to nonsmokers. I/O detection thresholds were also significantly elevated at high frequencies in smokers as compared to their nonsmoking counterparts. These findings indicate that smokers are at greater risk for cochlear damage than nonsmokers, and that DPOAE amplitudes and I/O detection thresholds may identify early changes in cochlear function in smokers.
本研究测量了畸变产物耳声发射（DPOAE）及DPOAE输入/输出（I/O）曲线，以评估吸烟对耳蜗功能的影响。根据自我报告的分别有5至8年吸烟史或无吸烟史，选取了24名年龄在20至30岁之间的健康成年人，其中12名吸烟者和12名不吸烟者。所有受试者均接受了鼓室导抗测试以排除中耳病变。常规（0.25 - 8 kHz）和超高频（UHF；10 - 20 kHz）听力测试显示两组的阈值均正常或符合年龄特征。DPOAE结果显示，与不吸烟者相比，吸烟者的DPOAE水平虽有小幅但显著的下降，且本底噪声无相应变化。与不吸烟的同龄人相比，吸烟者在高频时的I/O检测阈值也显著升高。这些发现表明，吸烟者比不吸烟者面临更大的耳蜗损伤风险，并且DPOAE幅值和I/O检测阈值可能识别出吸烟者耳蜗功能的早期变化。
