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告知患者其肺龄对戒烟率的影响:Step2quit随机对照试验

Effect on smoking quit rate of telling patients their lung age: the Step2quit randomised controlled trial.

作者信息

Parkes Gary, Greenhalgh Trisha, Griffin Mark, Dent Richard

机构信息

The Limes Surgery, Hoddesdon, Hertfordshire EN11 8EP.

出版信息

BMJ. 2008 Mar 15;336(7644):598-600. doi: 10.1136/bmj.39503.582396.25. Epub 2008 Mar 6.

Abstract

OBJECTIVE

To evaluate the impact of telling patients their estimated spirometric lung age as an incentive to quit smoking.

DESIGN

Randomised controlled trial.

SETTING

Five general practices in Hertfordshire, England.

PARTICIPANTS

561 current smokers aged over 35.

INTERVENTION

All participants were offered spirometric assessment of lung function. Participants in intervention group received their results in terms of "lung age" (the age of the average healthy individual who would perform similar to them on spirometry). Those in the control group received a raw figure for forced expiratory volume at one second (FEV1). Both groups were advised to quit and offered referral to local NHS smoking cessation services.

MAIN OUTCOME MEASURES

The primary outcome measure was verified cessation of smoking by salivary cotinine testing 12 months after recruitment. Secondary outcomes were reported changes in daily consumption of cigarettes and identification of new diagnoses of chronic obstructive lung disease.

RESULTS

Follow-up was 89%. Independently verified quit rates at 12 months in the intervention and control groups, respectively, were 13.6% and 6.4% (difference 7.2%, P=0.005, 95% confidence interval 2.2% to 12.1%; number needed to treat 14). People with worse spirometric lung age were no more likely to have quit than those with normal lung age in either group. Cost per successful quitter was estimated at 280 pounds sterling (366 euros, $556). A new diagnosis of obstructive lung disease was made in 17% in the intervention group and 14% in the control group; a total of 16% (89/561) of participants.

CONCLUSION

Telling smokers their lung age significantly improves the likelihood of them quitting smoking, but the mechanism by which this intervention achieves its effect is unclear.

TRIAL REGISTRATION

National Research Register N0096173751.

摘要

目的

评估告知患者其肺活量测定的预估肺龄对鼓励戒烟的影响。

设计

随机对照试验。

地点

英国赫特福德郡的5家普通诊所。

参与者

561名年龄超过35岁的当前吸烟者。

干预措施

所有参与者均接受肺功能的肺活量测定评估。干预组参与者收到以“肺龄”(在肺活量测定中表现与他们相似的健康个体的年龄)表示的结果。对照组参与者收到一秒用力呼气量(FEV1)的原始数据。两组均获建议戒烟,并被转介至当地国民保健署戒烟服务机构。

主要结局指标

主要结局指标为招募后12个月通过唾液可替宁检测证实的戒烟情况。次要结局指标为报告的每日吸烟量变化以及慢性阻塞性肺疾病新诊断病例的识别情况。

结果

随访率为89%。干预组和对照组在12个月时经独立验证的戒烟率分别为13.6%和6.4%(差异为7.2%,P = 0.005,95%置信区间为2.2%至12.1%;需治疗人数为14)。在两组中,肺龄较差者与肺龄正常者相比,戒烟的可能性并无更高。每成功戒烟一人的成本估计为280英镑(366欧元,556美元)。干预组有17%的参与者被新诊断为阻塞性肺疾病,对照组为14%;共有16%(89/561)的参与者。

结论

告知吸烟者其肺龄可显著提高他们戒烟的可能性,但该干预措施产生效果的机制尚不清楚。

试验注册

国家研究注册N0096173751。

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