Chen Ming-Huang, Hsiao Liang-Tsai, Chiou Tzeon-Jye, Liu Jin-Hwang, Gau Jyh-Pyng, Teng Hao-Wei, Wang Wei-Shu, Chao Ta-Chung, Yen Chueh-Chuan, Chen Po-Min
Division of Hematology & Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Ann Hematol. 2008 Jun;87(6):475-80. doi: 10.1007/s00277-008-0469-9. Epub 2008 Mar 8.
Several reports recently found that patients with B cell non-Hodgkin's lymphoma (NHL) had a higher carrier rate of hepatitis B surface antigen (HBsAg). The current study aimed to examine the hepatitis B virus (HBV) infection status of NHL patients in Taiwan, an HBV-endemic area. Serum HBV and serum hepatitis C virus were measured in 471 NHL patients and 1,013 non-lymphoma cancer patients enrolled between February 2000 and March 2007. Furthermore, nested polymerase chain reaction of HBV-DNA was used to examine the sera from selected patients in these two populations and healthy volunteers for the presence of occult HBV infection. The infection rates (as indicated by the rates of HBsAg and occult HBV) were compared between different groups. There was a higher incidence of HBV infection in B cell NHL patients (23.5%), especially patients with diffuse large B lymphoma, than solid tumor patients (15.6%, P = 0.001). Among HbsAg-negative patients, those with B cell NHL had a higher prevalence of occult HBV infection (6%) than those with non-lymphoma solid tumors and healthy volunteers, 0% and 0.9%, respectively (P = 0.005). B cell NHL patients, even HBsAg-negative B cell NHL patients, but not T cell NHL patients, have a higher incidence of HBV infection than patients with solid tumors. Our findings support the etiologic role of HBV infection in B cell NHL.
最近有几份报告发现，B细胞非霍奇金淋巴瘤（NHL）患者的乙肝表面抗原（HBsAg）携带率较高。本研究旨在调查台湾这一乙肝流行地区NHL患者的乙肝病毒（HBV）感染状况。对2000年2月至2007年3月期间纳入的471例NHL患者和1013例非淋巴瘤癌症患者检测了血清HBV和血清丙肝病毒。此外，采用巢式聚合酶链反应检测这两个人群中部分患者以及健康志愿者血清中隐匿性HBV感染情况。比较了不同组之间的感染率（以HBsAg和隐匿性HBV的发生率表示）。B细胞NHL患者的HBV感染发生率（23.5%）高于实体瘤患者（15.6%，P = 0.001），尤其是弥漫性大B淋巴瘤患者。在HBsAg阴性患者中，B细胞NHL患者的隐匿性HBV感染患病率（6%）高于非淋巴瘤实体瘤患者和健康志愿者，后两者分别为0%和0.9%（P = 0.005）。B细胞NHL患者，即使是HBsAg阴性的B细胞NHL患者，但不包括T细胞NHL患者，其HBV感染发生率高于实体瘤患者。我们的研究结果支持HBV感染在B细胞NHL发病中的病因学作用。
