Liu Wei-Ping, Zheng Wen, Wang Xiao-Pei, Song Yu-Qin, Xie Yan, Tu Mei-Feng, Lin Ning-Jing, Ping Ling-Yan, Ying Zhi-Tao, Deng Li-Juan, Zhang Chen, Zhu Jun
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China.
Zhonghua Xue Ye Xue Za Zhi. 2011 Aug;32(8):521-4.
To analyze the status of hepatitis B virus (HBV) infection in non-Hodgkin lymphoma (NHL) patients.
The serum HBV markers in NHL patients were detected by enzyme-linked immunosorbent assay (ELISA). The infection rate of HBV in NHL patients was compared with that in nationwide general population.
The positive rates of HBsAg, anti-HBs and anti-HBc in 405 cases of NHL were 11.6%, 39.8% and 47.9%, respectively, which were statistically different from those in general population (P < 0.01). The positive rates of HBsAg, anti-HBs and anti-HBc in B-cell NHL and T-cell NHL were 13.3% vs 7.1% (P = 0.083), 40.6% vs 37.5% (P = 0.567), 53.2% vs 33.9% (P = 0. 001), respectively. The HBV DNA positive rate was 23.7% in 93 cases of NHL, and was 50.0% in 38 cases of HBsAg-positive NHL while 5.5% in 55 cases of HBsAg-negative but HBcAb-positive NHL.
The infection rate of HBV in NHL patients is higher than that in general population, in which occult hepatitis B virus infection can not be ignored. The positive rate of anti-HBc in B-cell NHL is significantly higher than that in T-cell NHL. For NHL patients infected with HBV, prophylactic anti-HBV therapy to prevent viral reactivation should be given before the anti-cancer treatment. Further study in the relationship between HBV and NHL should be carried out in the future.
分析非霍奇金淋巴瘤（NHL）患者的乙型肝炎病毒（HBV）感染状况。
采用酶联免疫吸附试验（ELISA）检测NHL患者血清中的HBV标志物。将NHL患者的HBV感染率与全国普通人群的感染率进行比较。
405例NHL患者中，HBsAg、抗-HBs和抗-HBc的阳性率分别为11.6%、39.8%和47.9%，与普通人群相比差异有统计学意义（P<0.01）。B细胞NHL和T细胞NHL中HBsAg、抗-HBs和抗-HBc的阳性率分别为13.3%对7.1%（P=0.083）、40.6%对37.5%（P=0.567）、53.2%对33.9%（P=0.001）。93例NHL患者中HBV DNA阳性率为23.7%，38例HBsAg阳性的NHL患者中HBV DNA阳性率为50.0%，55例HBsAg阴性但抗-HBc阳性的NHL患者中HBV DNA阳性率为5.5%。
NHL患者的HBV感染率高于普通人群，其中隐匿性乙型肝炎病毒感染不容忽视。B细胞NHL的抗-HBc阳性率显著高于T细胞NHL。对于感染HBV的NHL患者，在抗癌治疗前应给予预防性抗HBV治疗以预防病毒再激活。未来应进一步研究HBV与NHL之间的关系。
