Patade Anagha, Devareddy Latha, Lucas Edralin A, Korlagunta Kiranmayi, Daggy Bruce P, Arjmandi Bahram H
Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.
J Womens Health (Larchmt). 2008 Apr;17(3):355-66. doi: 10.1089/jwh.2007.0359.
The objective of the study was to investigate the extent to which the daily incorporation of approximately 30 g of flaxseed, a rich source of lignans, omega-3 fatty acids, and fiber, for a period of 3 months into the diet of Native American postmenopausal women positively affects their lipid profiles.
Fifty-five mild to moderately hypercholesterolemic (> or =5.1 to < or =9.8 mmol/L) Native American postmenopausal women were randomly assigned to control (A), flaxseed (B) or flaxseed + additional oat bran fiber (C) groups. Overnight fasting venous blood was collected at baseline and at the end of the treatment period to analyze lipid parameters.
Dietary flaxseed supplementation lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) by approximately 7% and 10%, respectively. However, the levels of high-density lipoprotein (HDL) and triglyceride remained unaltered. No changes were observed in other clinical and hematological parameters.
The results of the present study indicate that Native American postmenopausal women benefit from regular consumption of flaxseed by reducing their risk of cardiovascular disease as seen from lowered LDL-C and total cholesterol levels.
本研究的目的是调查在3个月的时间里，美洲原住民绝经后女性的饮食中每日加入约30克富含木脂素、ω-3脂肪酸和纤维的亚麻籽，对她们的血脂状况产生何种积极影响。
55名轻度至中度高胆固醇血症（≥5.1至≤9.8 mmol/L）的美洲原住民绝经后女性被随机分为对照组（A）、亚麻籽组（B）或亚麻籽+额外燕麦麸纤维组（C）。在基线和治疗期结束时采集过夜空腹静脉血，以分析血脂参数。
膳食补充亚麻籽使总胆固醇和低密度脂蛋白胆固醇（LDL-C）分别降低了约7%和10%。然而，高密度脂蛋白（HDL）和甘油三酯水平保持不变。其他临床和血液学参数未观察到变化。
本研究结果表明，美洲原住民绝经后女性通过经常食用亚麻籽降低了LDL-C和总胆固醇水平，从而降低了心血管疾病风险，从中受益。
