Blasini Wilfredo, Saini Ritu, Vincek Vladimir
Department of Pathology, University of Miami School of Medicine.
Dermatol Online J. 2007 Jul 13;13(3):27.
A 12-month-old male presented with edematous purpuric plaques on the extremities (including the palms and soles), and violaceous targetoid macules on the hard palate and earlobes. The patient had an upper respiratory infection and conjunctivitis 10 days prior to the development of the skin lesions, and was vaccinated 3 weeks before this presentation. He was found to have increased IgA levels and increased ESR. Skin biopsies demonstrated leukocytoclastic vasculitis and IgA granular deposition on superficial dermal vessels. These findings are characteristic of acute hemorrhagic edema of infancy, an entity that must be distinguished from other leukocytoclastic vasculitis, especially Henoch-Schönlein purpura.
一名12个月大的男性患儿，四肢（包括手掌和足底）出现水肿性紫癜性斑块，硬腭和耳垂有紫罗兰色靶样斑疹。该患者在皮肤病变出现前10天有上呼吸道感染和结膜炎，此次就诊前3周接种过疫苗。发现其IgA水平升高，血沉加快。皮肤活检显示白细胞破碎性血管炎，真皮浅层血管有IgA颗粒沉积。这些表现是婴儿急性出血性水肿的特征，这一疾病必须与其他白细胞破碎性血管炎，尤其是过敏性紫癜相鉴别。
