Joly P, Prost C, Gaudemar M, Revuz J
Service de Dermatologie, Hôpital Henri-Mondor, Créteil.
Ann Dermatol Venereol. 1991;118(5):369-72.
An 18-year old male patients with tetracycline-resistant acne vulgaris was prescribed isotretinoin in daily doses of 0.5 mg/kg. Ten days later, he developed an acute episode of acne fulminans which was regressive. Subsequently, two attempts were made at reintroducing isotretinoin; the first one was followed by a new episode of acne fulminans and the second one, by ordinary myalgias, while the patient was still under corticosteroid therapy. A search in the literature yielded 14 cases of acne fulminans that had possibly been induced by isotretinoin. Doses and intervals between medication and acute manifestations varied, and the responsibility of isotretinoin was seldom demonstrated. Associations with erythema nodosum myalgias and arthralgias have been described. This rare adverse effect of isotretinoin therapy must be known. Its course and treatment are not different from those of ordinary acne fulminans.
一名18岁对四环素耐药的寻常痤疮男性患者，被处方异维A酸，每日剂量为0.5mg/kg。十天后，他出现了暴发性痤疮急性发作，呈退行性。随后，进行了两次重新引入异维A酸的尝试；第一次尝试后出现了新的暴发性痤疮发作，第二次尝试后，在患者仍接受皮质类固醇治疗时出现了普通肌痛。文献检索发现了14例可能由异维A酸诱发的暴发性痤疮病例。用药与急性表现之间的剂量和间隔各不相同，异维A酸的责任很少得到证实。已经描述了与结节性红斑、肌痛和关节痛的关联。必须了解异维A酸治疗的这种罕见不良反应。其病程和治疗与普通暴发性痤疮无异。
