Traupe H, von Mühlendahl K E, Brämswig J, Happle R
Department of Dermatology, University of Münster, West Germany.
Arch Dermatol. 1988 Mar;124(3):414-7.
Ulcerative acne was observed in three boys who underwent long-term treatment with high doses of testosterone for excessively tall stature. Even after withdrawal of testosterone therapy, this devastating type of acne still persisted for several months. After starting isotretinoin treatment, two cases progressed to full-blown acne fulminans with systemic manifestations. In these two cases, oral isotretinoin therapy induced multiple lesions of hyperproliferative granulation tissue resembling pyogenic granuloma. Topical steroid treatment proved to be beneficial for this adverse effect. Systemic corticosteroid treatment was administered in one case. High testosterone levels during puberty may be an important trigger mechanism of acne fulminans and may explain why this disease almost exclusively affects male adolescents.
三名身材过高接受大剂量睾酮长期治疗的男孩出现了溃疡性痤疮。即使停用睾酮治疗后，这种严重的痤疮仍持续了数月。开始异维A酸治疗后，两例进展为伴有全身表现的暴发性痤疮。在这两例中，口服异维A酸治疗引发了多个类似化脓性肉芽肿的增生性肉芽组织病变。局部使用类固醇治疗被证明对这种不良反应有益。其中一例进行了全身皮质类固醇治疗。青春期高睾酮水平可能是暴发性痤疮的重要触发机制，这或许可以解释为什么这种疾病几乎只影响男性青少年。
