Piestrzeniewicz Katarzyna, Łuczak Katarzyna, Komorowski Jan, Maciejewski Marek, Jankiewicz Wika Joanna, Goch Jan Henryk
Ist Department of Cardiology, Medical University of Łódź, Poland.
Metabolism. 2008 Apr;57(4):488-93. doi: 10.1016/j.metabol.2007.11.009.
The objective of the study was to assess the relation of resistin to the anthropometric parameters, metabolic risk factors, and C-reactive protein (CRP) in men with myocardial infarction. Subjects were 40 obese (age, 53.6 +/- 7.39 years; body mass index, > or =30 kg/m2) and 40 lean (age, 54.4 +/- 6.62 years; body mass index, <25 kg/m2) men with first acute myocardial infarction. Waist and hip circumferences, CRP, uric acid, fasting glucose, lipid profile, and blood resistin concentration were measured. In obese patients, triglycerides, fasting glucose, and CRP were significantly higher whereas high-density lipoprotein cholesterol was lower than in lean patients. The range of blood resistin concentration was 6.0 to 70.5 ng/mL: 27.84 +/- 12.15 ng/mL in obese subjects and 17.35 +/- 11.08 ng/mL in lean subjects (P < .0001). Significant positive correlation was revealed between blood resistin concentration and each of the analyzed anthropometric parameter and with fasting glucose, low-density lipoprotein cholesterol, and CRP, whereas negative relation was observed between resistin and high-density lipoprotein cholesterol. As revealed by univariate logistic regression analysis, risk of blood resistin concentration being greater than the median value (19.75 ng/mL) was increased by obesity, high-density lipoprotein cholesterol <40 mg/dL, hypertension, and CRP. In multivariate model, independent variables associated with higher median of resistin were obesity and CRP. Obesity increased 5.5-fold the probability of blood resistin concentration being greater than 19.75 ng/mL, whereas each 1-mg/dL increase in CRP increased this probability by 13%. In patients with acute myocardial infarction, obesity is positively related to blood resistin concentration. Resistin is likely to play a major role in the atherogenesis and its complications, and this action seems to be mostly related to the inflammatory reaction.
本研究的目的是评估抵抗素与心肌梗死男性患者的人体测量参数、代谢危险因素及C反应蛋白（CRP）之间的关系。研究对象为40名肥胖男性（年龄53.6±7.39岁；体重指数≥30kg/m²）和40名消瘦男性（年龄54.4±6.62岁；体重指数＜25kg/m²），均为首次发生急性心肌梗死。测量了腰围、臀围、CRP、尿酸、空腹血糖、血脂谱及血液抵抗素浓度。肥胖患者的甘油三酯、空腹血糖和CRP显著高于消瘦患者，而高密度脂蛋白胆固醇则低于消瘦患者。血液抵抗素浓度范围为6.0至70.5ng/mL：肥胖受试者为27.84±12.15ng/mL，消瘦受试者为17.35±11.08ng/mL（P＜0.0001）。血液抵抗素浓度与各分析人体测量参数、空腹血糖、低密度脂蛋白胆固醇及CRP之间均呈显著正相关，而抵抗素与高密度脂蛋白胆固醇呈负相关。单因素逻辑回归分析显示，肥胖、高密度脂蛋白胆固醇＜40mg/dL、高血压及CRP会增加血液抵抗素浓度高于中位数（19.75ng/mL）的风险。在多变量模型中，与抵抗素中位数较高相关的自变量为肥胖和CRP。肥胖使血液抵抗素浓度高于19.75ng/mL的概率增加5.5倍，而CRP每升高1mg/dL，该概率增加13%。在急性心肌梗死患者中，肥胖与血液抵抗素浓度呈正相关。抵抗素可能在动脉粥样硬化及其并发症中起主要作用，且这种作用似乎主要与炎症反应有关。
