Panico Salvatore, Palmieri Luigi, Donfrancesco Chiara, Vanuzzo Diego, Chiodini Paolo, Cesana Giancarlo, Ferrario Marco, Mattiello Amalia, Pilotto Lorenza, Sega Roberto, Giampaoli Simona, Stamler Jeremiah
Dipartimento di Medicina Clinica e Sperimentale, Federico II University, Via Pansini, 5, 80131 Naples, Italy.
Prev Med. 2008 Jul;47(1):53-60. doi: 10.1016/j.ypmed.2008.01.023. Epub 2008 Feb 9.
To estimate effects of weight change on incidence of major cardiovascular events in the Italian population-based Progetto CUORE.
Prospective observation in 12 Italian population-based cohorts on etiology of cardiovascular disease. Twenty-thousand six-hundred-forty-seven men and women aged 35-69 years without previous CVD, examined at baseline between 1984 and 1993 and followed for median time 8.5 years, with validated first cardiovascular events. Standardised anthropometric variables, lifestyle and biochemical risk factors for CVD; major cardiovascular events as end-points.
Linear regression between BMI and major CVD risk factors was combined with Cox coefficients from a prediction model of CVD, CHD and stroke using major risk factors as dependent variables. Estimated cardiovascular risk reductions with BMI lowered by 1 to 3 U were: for men 3.8% to 10.9% for all cardiovascular events, 4.2% to 12.1% for CHD, and 2.3% to 6.9% for stroke; for women 2.8% to 8.1% for all cardiovascular events, 3.4% to 9.8% for CHD, and 2.1% to 6.2% for stroke.
Body weight level influences cardiovascular disease risk in the Italian population.
在意大利基于人群的“CUORE项目”中评估体重变化对主要心血管事件发生率的影响。
对12个意大利基于人群的心血管疾病病因队列进行前瞻性观察。26447名年龄在35 - 69岁之间、无既往心血管疾病史的男性和女性，于1984年至1993年期间进行基线检查，并随访了8.5年的中位时间，记录首次发生的经证实的心血管事件。采用标准化人体测量变量、生活方式和心血管疾病的生化危险因素；以主要心血管事件作为终点。
将体重指数（BMI）与主要心血管疾病危险因素之间的线性回归与以主要危险因素为因变量的心血管疾病、冠心病和中风预测模型的Cox系数相结合。BMI降低1至3个单位时，估计的心血管疾病风险降低幅度为：男性所有心血管事件降低3.8%至10.9%，冠心病降低4.2%至12.1%，中风降低2.3%至6.9%；女性所有心血管事件降低2.8%至8.1%，冠心病降低3.4%至9.8%，中风降低2.1%至6.2%。
体重水平影响意大利人群的心血管疾病风险。
