Li Xin, Jin Yichen, Bandinelli Stefania, Ferrucci Luigi, Tanaka Toshiko, Talegawkar Sameera A
Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC 20052, USA.
Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50137 Florence, Italy.
Eur J Investig Health Psychol Educ. 2025 Sep 8;15(9):181. doi: 10.3390/ejihpe15090181.
Our study examined the associations between overall cardiovascular health (CVH) and the risk of disability in older adults over 16 years of follow-up. Data from the InCHIANTI study were used and included 928 participants aged 65 years and older. Overall CVH was measured using the "Life's Essential 8" (LE8) metric. Disability status was assessed by the Activities of Daily Living (ADL) and the Instrumental Activities of Daily Living (IADL). Higher overall LE8 score at baseline was associated with lower risks of having the first ADL among males (hazard ratio [HR] = 0.66, = 0.001) and IADL disability event (HR = 0.89, = 0.016) using the Cox proportional hazards model. Higher LE8 scores were also associated with ADL (odds ratio [OR] (females) = 0.80, = 0.034; OR (males) = 0.55, < 0.001) and IADL worsening (OR = 0.72, < 0.001) using Generalized Estimating Equation models. Among older adults, better CVH assessed by the LE8 metric was associated with lower risk of ADL and IADL disabilities and their worsening over time. These findings underscore the importance of promoting CVH as a key strategy to support healthy aging and reduce disability burden. Public health interventions that target CVH components may be effective in preserving functional independence among older populations.
我们的研究通过16年的随访，调查了老年人群总体心血管健康（CVH）与残疾风险之间的关联。研究使用了InCHIANTI研究的数据，包括928名65岁及以上的参与者。总体CVH采用“生命八大要素”（LE8）指标进行衡量。残疾状况通过日常生活活动能力（ADL）和工具性日常生活活动能力（IADL）进行评估。使用Cox比例风险模型，基线时较高的总体LE8得分与男性首次出现ADL残疾（风险比[HR]=0.66，P=0.001）和IADL残疾事件（HR=0.89，P=0.016）的较低风险相关。使用广义估计方程模型，较高的LE8得分也与ADL恶化（优势比[OR]（女性）=0.80，P=0.034；OR（男性）=0.55，P<0.001）和IADL恶化（OR=0.72，P<0.001）相关。在老年人中，通过LE8指标评估的更好的CVH与ADL和IADL残疾风险降低及其随时间的恶化相关。这些发现强调了促进CVH作为支持健康老龄化和减轻残疾负担的关键策略的重要性。针对CVH各组成部分的公共卫生干预措施可能对维持老年人群的功能独立性有效。
