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利用特定DNA芯片筛选衰老相关基因揭示胰岛素样生长因子结合蛋白3在人二倍体成纤维细胞早衰中的作用。

Screening of senescence-associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts.

作者信息

Debacq-Chainiaux Florence, Pascal Thierry, Boilan Emmanuelle, Bastin Coralie, Bauwens Emilie, Toussaint Olivier

机构信息

Unit of Research on Cellular Biology, Department of Biology, University of Namur, Rue de Bruxelles, B-5000 Namur, Belgium.

出版信息

Free Radic Biol Med. 2008 May 15;44(10):1817-32. doi: 10.1016/j.freeradbiomed.2008.02.001. Epub 2008 Feb 20.

DOI:10.1016/j.freeradbiomed.2008.02.001
PMID:18329388
Abstract

Repeated exposures to sublethal concentrations of tert-butylhydroperoxide and ethanol trigger premature senescence of WI-38 human diploid fibroblasts. We found 16 replicative senescence-related genes with similar alterations in expression level in replicative senescence and two models of stress-induced premature senescence. Among these genes was IGFBP-3. Using a siRNA approach, we showed that IGFBP-3 regulates the appearance of several biomarkers of senescence after repeated exposures of WI-38 fibroblasts to tert-butylhydroperoxide and ethanol.

摘要

反复暴露于亚致死浓度的叔丁基过氧化氢和乙醇会引发WI-38人二倍体成纤维细胞的早衰。我们发现16个与复制性衰老相关的基因，其在复制性衰老以及两种应激诱导的早衰模型中的表达水平有相似变化。这些基因中包括IGFBP-3。通过小干扰RNA方法，我们表明，在WI-38成纤维细胞反复暴露于叔丁基过氧化氢和乙醇后，IGFBP-3调节几种衰老生物标志物的出现。

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