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阻塞性睡眠呼吸暂停患者的日间驾驶模拟表现与嗜睡情况

Daytime driving simulation performance and sleepiness in obstructive sleep apnoea patients.

作者信息

Pizza Fabio, Contardi Sara, Ferlisi Monica, Mondini Susanna, Cirignotta Fabio

机构信息

Unit of Neurology, S.Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy.

出版信息

Accid Anal Prev. 2008 Mar;40(2):602-9. doi: 10.1016/j.aap.2007.08.014. Epub 2007 Sep 19.

Abstract

BACKGROUND

Sleepiness related car accidents are common in obstructive sleep apnoea syndrome (OSAS) patients. The objective measurements of sleepiness used in clinical setting quantify the tendency to fall asleep in quiet situations that are completely different from driving.

METHODS

We studied 30 OSAS patients with subjective (subjective sleepiness scales) and objective (multiple sleep latency test, MSLT) sleepiness measurements, associated with driving simulation test (DST), previously validated in young healthy subjects. The results of subjective and objective sleepiness tests were compared with simulated driving performance in order to evaluate the suitability of our DST for measuring alertness.

RESULTS

Subjective and objective sleepiness measurements were significantly correlated with driving performance on the simulator. The most significant correlates of sleepiness were the measures of the primary vehicle control task on the simulator: lane position variability and crash data. The comparison of DST and MSLT results suggested our driving simulated approach could be used to evaluate daytime sleepiness in the clinical setting of OSAS patients.

CONCLUSIONS

Our DST is a suitable objective tool to detect sleepiness in OSAS patients, and could be useful in the clinical setting of sleep medicine and research.

摘要

背景

与嗜睡相关的车祸在阻塞性睡眠呼吸暂停综合征(OSAS)患者中很常见。临床环境中用于测量嗜睡的客观指标量化的是在与驾驶完全不同的安静环境中入睡的倾向。

方法

我们研究了30名OSAS患者,采用主观(主观嗜睡量表)和客观(多次睡眠潜伏期试验,MSLT)嗜睡测量方法,并结合驾驶模拟试验(DST),该试验先前已在年轻健康受试者中得到验证。将主观和客观嗜睡测试的结果与模拟驾驶表现进行比较,以评估我们的DST在测量警觉性方面的适用性。

结果

主观和客观嗜睡测量结果与模拟器上的驾驶表现显著相关。嗜睡最显著的相关因素是模拟器上主要车辆控制任务的指标:车道位置变异性和碰撞数据。DST和MSLT结果的比较表明,我们的驾驶模拟方法可用于评估OSAS患者临床环境中的日间嗜睡情况。

结论

我们的DST是检测OSAS患者嗜睡情况的合适客观工具,在睡眠医学临床环境和研究中可能有用。

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