Jaroszewski Dawn E, Huh Joseph, Chu Danny, Malaisrie S Chris, Riffel Anthony D, Gordon Howard S, Wang Xing Li, Bakaeen Faisal
Michael E. DeBakey Veterans Affairs Hospital, Houston, Tex 77030, USA.
J Thorac Cardiovasc Surg. 2008 Mar;135(3):648-55. doi: 10.1016/j.jtcvs.2007.09.021.
Recent literature has questioned the efficacy of routine detailed preoperative cardiac ischemia testing and preoperative cardiac intervention before noncardiac surgical procedures.
We performed a retrospective review of patients undergoing thoracotomy (n = 294) between January of 1999 and January of 2005.
The median age was 62 years. Detailed preoperative cardiac testing was performed on 184 patients (63%) and went beyond a thorough history, physical examination, and electrocardiogram to include at least one of the following: dobutamine stress echo (n = 116), nuclear stress test (n = 66), treadmill test (n = 8), and coronary angiogram (n = 40). Evidence for coronary disease was detected in 43% of tests (99/230) performed. Revascularization was performed in 10% of all patients (4/40) who underwent coronary angiography. Postoperative myocardial infarction occurred in 7 patients (2.4%) with 4 myocardial infarction-related mortalities. No significant difference was found in the incidence of myocardial infarction in patients with (n = 184) or without (n = 110) detailed preoperative cardiac testing (3.3% vs 0.9%, P = .29). Of the 4 patients (1.4%) who underwent revascularization to treat coronary lesions identified during prethoracotomy workup, 2 had a myocardial infarction, 1 of which was caused by thrombosis of a coronary stent. In the subset of patients who underwent lobectomy (n = 149), detailed cardiac testing was performed on 107 patients (72%). The incidence of myocardial infarction was similar in tested and untested patients (2.8% vs 2.4% respectively, P = 1.0).
Selective use of detailed preoperative cardiac testing refines risk stratification and identifies patients for corrective cardiac interventions; however, it did not prove fully protective against myocardial infarction after thoracotomy in our study.
近期文献对非心脏手术前常规进行详细的术前心脏缺血检测及术前心脏干预的疗效提出了质疑。
我们对1999年1月至2005年1月期间接受开胸手术的患者(n = 294)进行了回顾性研究。
中位年龄为62岁。184例患者(63%)进行了详细的术前心脏检测,检测内容超出了全面的病史、体格检查和心电图,至少包括以下一项:多巴酚丁胺负荷超声心动图(n = 116)、核素负荷试验(n = 66)、平板运动试验(n = 8)和冠状动脉造影(n = 40)。在进行的检测中,43%(99/230)检测出冠状动脉疾病证据。在接受冠状动脉造影的所有患者中,10%(4/40)进行了血运重建。7例患者(2.4%)发生术后心肌梗死,其中4例与心肌梗死相关死亡。术前进行详细心脏检测的患者(n = 184)和未进行详细心脏检测的患者(n = 110)心肌梗死发生率无显著差异(3.3%对0.9%,P = 0.29)。在开胸术前检查中接受血运重建以治疗冠状动脉病变的4例患者(1.4%)中,2例发生心肌梗死,其中1例由冠状动脉支架血栓形成引起。在接受肺叶切除术的患者亚组(n = 149)中,107例患者(72%)进行了详细的心脏检测。检测组和未检测组患者的心肌梗死发生率相似(分别为2.8%和2.4%,P = 1.0)。
选择性使用详细的术前心脏检测可优化风险分层,并识别需要进行心脏矫正干预的患者;然而,在我们的研究中,它并未完全预防开胸术后的心肌梗死。