Oliveira Erica R, Fothergill Annette, Kirkpatrick William R, Patterson Thomas F, Redding Spencer W
Department of General Dentistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Apr;105(4):457-9. doi: 10.1016/j.tripleo.2007.12.003.
Antifungal susceptibility of micafungin against isolates of C. glabrata was performed to evaluate the hypothesis that micafungin may be a suitable alternative in treating those patients whose infections are from C. glabrata and have developed resistance to fluconazole.
A total of 119 clinical isolates were obtained from the oral cavity of 22 patients with oropharyngeal candidiasis or oral colonization with C. glabrata. All strains evaluated were from patients who had either HIV infection or were receiving radiation therapy for head and neck cancer. Inocula were prepared using Clinical Laboratory and Standards Institute (CLSI) M27-A2 guidelines. The plates were incubated at 35 degrees C and the minimum inhibitory concentrations (MICs) were determined at 24 and 48 hours.
Micafungin exhibited good in vitro activity against most isolates, including those showing marked resistance to fluconazole.
Micafungin has excellent antifungal effects in vitro against C. glabrata isolates and appears to be a good treatment option even against those isolates resistant to fluconazole. A clinical trial should be performed to confirm these findings.
对光滑念珠菌分离株进行米卡芬净的抗真菌药敏试验，以评估米卡芬净可能是治疗那些感染光滑念珠菌且对氟康唑耐药的患者的合适替代药物这一假说。
从22例患有口咽念珠菌病或口腔光滑念珠菌定植的患者口腔中获取了总共119株临床分离株。所有评估的菌株均来自感染人类免疫缺陷病毒（HIV）或正在接受头颈癌放射治疗的患者。按照临床实验室标准协会（CLSI）M27 - A2指南制备接种物。平板在35℃下孵育，并在24小时和48小时测定最低抑菌浓度（MIC）。
米卡芬净对大多数分离株表现出良好的体外活性，包括那些对氟康唑有明显耐药性的分离株。
米卡芬净在体外对光滑念珠菌分离株具有优异的抗真菌作用，即使对那些对氟康唑耐药的分离株似乎也是一个良好的治疗选择。应进行临床试验以证实这些发现。
