Imperiale Michael J
Department of Microbiology and Immunology, University of Michigan Medical School, 1500 E. Medical Center Drive, 6304 Cancer Center, Ann Arbor, MI 48109, USA.
Cell Host Microbe. 2008 Mar 13;3(3):119-20. doi: 10.1016/j.chom.2008.02.007.
While adenovirus holds many advantages as a vector for gene delivery, much of its full potential has been limited by the tendency of the most commonly used vectors to target the liver upon systemic delivery, resulting in unacceptable toxicity. Recently in Cell, Waddington et al. unmasked the virus-host interactions that lead to hepatic transduction. The results point a way toward avoiding this pathway during development of future generations of adenovirus vectors.
虽然腺病毒作为基因传递载体有许多优点，但其大部分潜力受到常用载体在全身给药时倾向于靶向肝脏的限制，从而导致不可接受的毒性。最近，沃丁顿等人在《细胞》杂志上揭示了导致肝脏转导的病毒与宿主的相互作用。这些结果为在下一代腺病毒载体的开发过程中避免这条途径指明了方向。
