Amin Daniel Ndem, Masocha Willias, Ngan'dwe Kalungwana, Rottenberg Martin, Kristensson Krister
Department of Neuroscience, Karolinska Institutet, SE 171 77 Stockholm, Sweden.
Acta Trop. 2008 Apr;106(1):72-4. doi: 10.1016/j.actatropica.2008.01.005. Epub 2008 Feb 2.
The effect of treatment on relapses of Trypanosoma brucei (T. b.) brucei infections in mice in relation to passage of the parasites across the blood-brain barrier (BBB) as visualized by immunohistochemistry was studied. Three daily intraperitoneal injections of 20mg/kg suramin starting at 15 days post-infection (p.i.), when trypanosomes had begun to traverse the BBB, were curative, but not when starting at 21 days p.i. when parasite brain invasion was more pronounced. Relapses occurred in all mice after one or two daily injections of suramin starting at 15 days p.i., but they were delayed when treatment was supplemented with minocycline, which impedes penetration of T. b. brucei into the brain. This study supports the notion that suramin may be effective even when minor parasite neuroinvasion has appeared in African trypanosomiasis and it shows that minocyline can affect relapses of the disease.
研究了治疗对小鼠布氏布氏锥虫感染复发的影响，该影响与通过免疫组织化学观察到的寄生虫穿越血脑屏障（BBB）有关。感染后15天（p.i.），当锥虫开始穿越血脑屏障时，每天腹腔注射20mg/kg苏拉明，连续注射三天可治愈感染，但在感染后21天开始注射则无效，此时寄生虫对脑部的侵袭更为明显。从感染后15天开始，每天注射一或两次苏拉明，所有小鼠都会复发，但当治疗辅以米诺环素时，复发会延迟，因为米诺环素会阻碍布氏布氏锥虫进入大脑。这项研究支持了以下观点：即使在非洲锥虫病中出现轻微的寄生虫神经侵袭时，苏拉明可能仍然有效，并且表明米诺环素可以影响该疾病的复发。
