Huang Hui-Chi, Liaw Chia-Ching, Zhang Li-Jie, Ho Hsi-Uo, Kuo Li-Ming Yang, Shen Ya-Ching, Kuo Yao-Haur
National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, ROC.
Phytochemistry. 2008 May;69(7):1597-603. doi: 10.1016/j.phytochem.2008.01.005. Epub 2008 Mar 10.
Oleanane-type triterpenoidal saponins, hydrocosisaponins A-F (1-6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques ((13)C, (1)H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.
从积雪草中分离出了齐墩果烷型三萜皂苷——羟基积雪草皂苷A - F（1 - 6），以及一种已知的皂苷——积雪草苷VII（7）。它们的结构是通过包括核磁共振光谱技术（（13）C、（1）H、COSY、HMQC、HMBC、TOCSY和NOESY）在内的光谱分析确定的。生物学评价表明，具有四个糖单元（三个d - 葡萄糖和一个l - 阿拉伯糖）的皂苷（4 - 7）对KB、Daoy和WiDr人肿瘤细胞系表现出中等程度的细胞毒性。
