假连翘中的新型三萜皂苷及其细胞毒性活性。
New triterpene saponins from Duranta repens Linn. and their cytotoxic activity.
作者信息
Ahmed Wafaa S, Mohamed Mona A, El-Dib Rabab A, Hamed Manal M
机构信息
Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Giza, Egypt.
出版信息
Molecules. 2009 May 25;14(5):1952-65. doi: 10.3390/molecules14051952.
From the leaves of Duranta repens (Verbenaceae) two new triterpene saponins, named durantanin IV (1) and V (2)were isolated.In addition, ten known compounds were isolated, namely a bidesmosidic saponin, oleanolic acid, three phenylethanoids and five flavonoids. All metabolites were isolated for the first time from this genus except for 3 (oleanolic acid) and 7 (E/Z acteoside). The structures were determined mainly by spectroscopic methods (UV, IR, HRESI-MS, (1)H-, (13)C-NMR, (1)H-(1)H COSY, HSQC and HMBC). Cytotoxic screening of the chloroform, ethyl acetate and methanol extracts was carried out on brine shrimps. In addition, the investigated methanol extract and compounds 1, 2 and 7 showed significant cytotoxic activity against a HepG2 cell line.
从假连翘（马鞭草科）的叶子中分离出两种新的三萜皂苷，分别命名为假连翘苷IV（1）和V（2）。此外，还分离出了十种已知化合物，即一种双糖链皂苷、齐墩果酸、三种苯乙醇类化合物和五种黄酮类化合物。除了3（齐墩果酸）和7（E/Z 紫草酸）外，所有代谢产物均首次从该属植物中分离得到。结构主要通过光谱方法（紫外、红外、高分辨电喷雾电离质谱、氢核磁共振、碳核磁共振、氢-氢化学位移相关谱、异核单量子相干谱和异核多键相关谱）确定。对氯仿、乙酸乙酯和甲醇提取物进行了卤虫细胞毒性筛选。此外，所研究的甲醇提取物以及化合物1、2和7对肝癌细胞系HepG2显示出显著的细胞毒性活性。
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