Xiao Lan, Wang Feng, Li Huan-De, Zhao Xu-Yuan
Clinical Pharmacy Laboratory, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(23):2534-8.
Studying the metabolic pharmacokinetic of baicalin of Qingkailing injection in rat, to search for effector substance of Qingkailing injection in vivo.
Qingkailing sterile injection powder was given by caudal vein, then blood, liver and lung were collected in various time, the concentration of baicalin from samples were determined by HPLC-MS. Pharmacokinetic evaluation was carried out using the 3P87.
After Qingkailing injection, Baicalin was consistent with two-compartment model in rat. 45 min, the concentration of baicalin in hepatic tissue reached maximum, followeded by decrease sharply, 120 min began to rise slowly, present double hump phenomenon. In lung, baicalin concentration was far more than in liver, was eliminated more slowly, but they have the same t(max).
After Qingkailing injection, baicalin distributed quickly to liver and lung, baicalin is one of effector substance of qingkailing injection in vivo. Baicalin might have hepatoenteral circulation.
研究清开灵注射液中黄芩苷在大鼠体内的代谢药动学，寻找清开灵注射液在体内的效应物质。
尾静脉注射清开灵无菌粉针剂，于不同时间采集血、肝、肺，采用HPLC-MS法测定样品中黄芩苷的浓度，用3P87进行药动学评价。
清开灵注射液给药后，黄芩苷在大鼠体内符合二室模型。45分钟时，肝组织中黄芩苷浓度达峰值，随后急剧下降，120分钟时开始缓慢上升，呈现双峰现象。肺中黄芩苷浓度远高于肝中，消除较慢，但二者t(max)相同。
清开灵注射液给药后，黄芩苷迅速分布至肝和肺，黄芩苷是清开灵注射液在体内的效应物质之一。黄芩苷可能存在肝肠循环。
