Lew D J, Dulić V, Reed S I
Department of Molecular Biology, MB7 Scripps Research Institute, La Jolla, California 92037.
Cell. 1991 Sep 20;66(6):1197-206. doi: 10.1016/0092-8674(91)90042-w.
We have isolated a number of cDNAs derived from human mRNAs that are able to substitute for G1 cyclin genes in S. cerevisiae. Several of these encode human cyclins A, B1, and B2. Three novel genes have been identified, which we call cyclins C, D, and E. The novel proteins are sufficiently distantly related to the other members of the cyclin family and to each other as to constitute three new classes of cyclins. Cyclin C and E mRNAs accumulate periodically through the cell cycle, peaking at different times in G1.
我们已经分离出了许多源自人类mRNA的cDNA，它们能够替代酿酒酵母中的G1细胞周期蛋白基因。其中有几种编码人类细胞周期蛋白A、B1和B2。我们还鉴定出了三个新基因，分别称为细胞周期蛋白C、D和E。这些新蛋白质与细胞周期蛋白家族的其他成员以及彼此之间的关系足够疏远，从而构成了三类新的细胞周期蛋白。细胞周期蛋白C和E的mRNA在整个细胞周期中周期性积累，在G1期的不同时间达到峰值。
