Ayubi F S, Armstrong P J, Mattia M S, Parker D M
General Surgery Service, Eisenhower Army Medical Center, Fort Gordon, GA 30905, USA.
Hernia. 2008 Aug;12(4):373-8. doi: 10.1007/s10029-008-0359-z. Epub 2008 Mar 11.
This study compared two porcine-derived grafts Permacol (Tissue Science Laboratory, Covington, GA, USA) and Surgisis (Cook Surgical, Bloomington, IN, USA) in terms of strength of incorporation (SOI), incorporation of host tissue, and adhesion formation using a rat model.
A prospective randomized study using 48 Sprague-Dawley rats. A standardized 1.5 x 5 cm fascial defect was created and repaired with either Permacol or Surgisis grafts. The rats were then sacrificed at 3, 14, 28, or 60 days. The specimens were examined for SOI, neovascularization, collagen deposition, collagen organization, and adhesion formation.
Surgisis had significantly greater SOI than Permacol at 28 (0.115 vs. 0.0754 Mpa) and 60 days (0.131 vs. 0.635 Mpa). Surgisis had significantly more collagen deposition and neovascularization than Permacol at 60 days. The area of adhesions was not significantly different between Surgisis and Permacol.
Surgisis is superior to Permacol in terms of SOI and tissue ingrowth at 60 days. Furthermore, Surgisis strengthened over time whereas Permacol decreased in strength.
本研究使用大鼠模型，比较了两种猪源移植物Permacol（美国佐治亚州卡温顿组织科学实验室）和Surgisis（美国印第安纳州布卢明顿库克外科公司）在整合强度（SOI）、宿主组织整合及粘连形成方面的差异。
一项前瞻性随机研究，使用48只Sprague-Dawley大鼠。制作一个标准化的1.5×5厘米筋膜缺损，并用Permacol或Surgisis移植物进行修复。然后在3、14、28或60天时处死大鼠。检查标本的SOI、新生血管形成、胶原沉积、胶原组织及粘连形成情况。
在28天（0.115对0.0754兆帕）和60天（0.131对0.635兆帕）时，Surgisis的SOI显著高于Permacol。在60天时，Surgisis的胶原沉积和新生血管形成明显多于Permacol。Surgisis和Permacol之间的粘连面积无显著差异。
在60天时，Surgisis在SOI和组织长入方面优于Permacol。此外，Surgisis的强度随时间增强，而Permacol的强度下降。
