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[心脏再同步治疗程控优化中的新技术]

[New technologies in the optimization of CRT programming].

作者信息

Kloppe A, Lemke B, Zarse M

机构信息

Innere Medizin III, Abteilung für Kardiologie and Angiologie, Klinikum Lüdenscheid, Paulmannshöher Str. 14, 58515 Lüdenscheid, Germany.

出版信息

Herzschrittmacherther Elektrophysiol. 2008 Mar;19(1):19-29. doi: 10.1007/s00399-008-0596-y.

DOI:10.1007/s00399-008-0596-y
PMID:18330672
Abstract

After implanting a CRT device, consistent and scheduled patient follow-up is mandatory. Besides determining electrode parameters and reviewing arrhythmic episodes, these follow-ups focus on monitoring and optimizing congestive heart failure therapy. Therefore new CRT devices present methods for heart failure surveillance and telemetric transmission of the acquired data, which allows the physician to respond immediately to the varying needs of the respective heart failure patient. In addition to cardiac resynchronization, optimization of atrioventricular (AV) and interventricular (VV) delay provide major hemodynamic benefits. As echocardiographic optimization of AV and VV delay is time consuming it is often not feasible during daily clinical practice. Therefore implemented algorithms that automatically determine and adapt AV and VV delays with respect to the fluctuating needs of the patients are essential. This article presents the current state of monitoring and optimization methods in CRT devices.

摘要

植入心脏再同步治疗(CRT)设备后,对患者进行持续且定期的随访是必不可少的。除了确定电极参数和回顾心律失常事件外,这些随访还着重于监测和优化充血性心力衰竭治疗。因此,新型CRT设备具备心力衰竭监测方法以及所采集数据的遥测传输功能,这使得医生能够立即对各个心力衰竭患者的不同需求做出反应。除心脏再同步外,优化房室(AV)和心室间(VV)延迟可带来显著的血流动力学益处。由于通过超声心动图优化AV和VV延迟耗时较长,在日常临床实践中往往不可行。因此,实施能够根据患者不断变化的需求自动确定并调整AV和VV延迟的算法至关重要。本文介绍了CRT设备中监测和优化方法的当前状况。

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1
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2
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本文引用的文献

1
[A simple method for AV-delay determination in dual chamber pacemakers].[双腔起搏器中房室延迟测定的一种简单方法]
Herzschrittmacherther Elektrophysiol. 2000 Dec;11(4):244-53. doi: 10.1007/s003990070023.
2
Intracardiac impedance monitors hemodynamic deterioration in a chronic heart failure pig model.心内阻抗监测慢性心力衰竭猪模型中的血流动力学恶化情况。
J Cardiovasc Electrophysiol. 2007 Sep;18(9):985-90. doi: 10.1111/j.1540-8167.2007.00868.x. Epub 2007 Jun 6.
3
A prospective comparison of AV delay programming methods for hemodynamic optimization during cardiac resynchronization therapy.
心脏再同步治疗期间用于血流动力学优化的房室延迟程控方法的前瞻性比较。
J Cardiovasc Electrophysiol. 2007 May;18(5):490-6. doi: 10.1111/j.1540-8167.2007.00770.x. Epub 2007 Feb 21.
4
Randomized comparison of simultaneous biventricular stimulation versus optimized interventricular delay in cardiac resynchronization therapy. The Resynchronization for the HemodYnamic Treatment for Heart Failure Management II implantable cardioverter defibrillator (RHYTHM II ICD) study.心脏再同步治疗中同步双心室刺激与优化心室间延迟的随机对照研究。心力衰竭管理II型植入式心脏复律除颤器血流动力学治疗再同步(RHYTHM II ICD)研究。
Am Heart J. 2006 May;151(5):1050-8. doi: 10.1016/j.ahj.2005.08.019.
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Preserved heart rate variability identifies low-risk patients with nonischemic dilated cardiomyopathy: results from the DEFINITE trial.保留的心率变异性可识别非缺血性扩张型心肌病的低风险患者:DEFINITE试验结果
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6
Understanding nonresponders of cardiac resynchronization therapy--current and future perspectives.了解心脏再同步治疗无反应者——现状与未来展望
J Cardiovasc Electrophysiol. 2005 Oct;16(10):1117-24. doi: 10.1111/j.1540-8167.2005.40829.x.
7
Intrathoracic impedance monitoring in patients with heart failure: correlation with fluid status and feasibility of early warning preceding hospitalization.心力衰竭患者的胸腔内阻抗监测:与液体状态的相关性及住院前早期预警的可行性
Circulation. 2005 Aug 9;112(6):841-8. doi: 10.1161/CIRCULATIONAHA.104.492207. Epub 2005 Aug 1.
8
The effect of cardiac resynchronization on morbidity and mortality in heart failure.心脏再同步化治疗对心力衰竭患者发病率和死亡率的影响。
N Engl J Med. 2005 Apr 14;352(15):1539-49. doi: 10.1056/NEJMoa050496. Epub 2005 Mar 7.
9
Echocardiographic parameters of ventricular dyssynchrony validation in patients with heart failure using sequential biventricular pacing.使用序贯双心室起搏对心力衰竭患者心室不同步进行超声心动图参数验证
J Am Coll Cardiol. 2004 Dec 7;44(11):2157-65. doi: 10.1016/j.jacc.2004.08.065.
10
Continuous autonomic assessment in patients with symptomatic heart failure: prognostic value of heart rate variability measured by an implanted cardiac resynchronization device.有症状心力衰竭患者的持续自主神经功能评估:植入式心脏再同步装置测量心率变异性的预后价值
Circulation. 2004 Oct 19;110(16):2389-94. doi: 10.1161/01.CIR.0000139841.42454.78. Epub 2004 Aug 16.