Chittiprol Seetharamaiah, Venkatasubramanian Ganesan, Neelakantachar Narendran, Allha Naveen, Shetty Kurudunje Taranath, Gangadhar Bangalore N
Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India.
Brain Behav Immun. 2009 Feb;23(2):189-92. doi: 10.1016/j.bbi.2008.08.007. Epub 2008 Sep 3.
Studies examining immune dysfunction in schizophrenia have reported decreased type-1 T-helper cell specific immunity (Th1) and increased type-2 T-helper cell specific immunity (Th2) and related abnormalities in inflammatory system. Beta2-Microglobulin (beta2M) influences the development of dendritic cells, which play a significant role in regulating the differentiation of naive CD4+ T cells into Th1 or Th2 lineages. The present study examined serum beta2M in antipsychotic-naïve schizophrenia patients (n=43) in comparison with age, sex, handedness and socioeconomic status matched healthy controls (n=43). Serum beta2M was significantly higher in schizophrenia patients (1692.6+/-354.4 ng/mL) than healthy controls (1409.6+/-246.9 ng/mL) (t=4.3; p<0.0001). There was a significant positive correlation between beta2M level and total psychopathology score (r=0.32; p=0.035). These novel observations suggest that beta2M abnormalities might have a potential association with the pathogenesis of schizophrenia.
研究精神分裂症免疫功能障碍的报告显示，1型辅助性T细胞特异性免疫（Th1）降低，2型辅助性T细胞特异性免疫（Th2）增加，且炎症系统存在相关异常。β2微球蛋白（β2M）影响树突状细胞的发育，而树突状细胞在调节初始CD4 + T细胞向Th1或Th2谱系的分化中起重要作用。本研究检测了43例未使用过抗精神病药物的精神分裂症患者的血清β2M，并与年龄、性别、利手和社会经济地位相匹配的43名健康对照者进行比较。精神分裂症患者的血清β2M（1692.6±354.4 ng/mL）显著高于健康对照者（1409.6±246.9 ng/mL）（t = 4.3；p < 0.0001）。β2M水平与总精神病理学评分之间存在显著正相关（r = 0.32；p = 0.035）。这些新发现表明，β2M异常可能与精神分裂症的发病机制存在潜在关联。
