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Dynamic epigenetic regulation of initial O-glycosylation by UDP-N-Acetylgalactosamine:Peptide N-acetylgalactosaminyltransferases. site-specific glycosylation of MUC1 repeat peptide influences the substrate qualities at adjacent or distant Ser/Thr positions.UDP-N-乙酰半乳糖胺对初始O-糖基化的动态表观遗传调控:肽N-乙酰半乳糖胺基转移酶。MUC1重复肽的位点特异性糖基化影响相邻或远处丝氨酸/苏氨酸位置的底物性质。
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Diverse IgG serum response to novel glycopeptide epitopes detected within immunodominant stretches of Epstein-Barr virus glycoprotein 350/220: diagnostic potential of O-glycopeptide microarrays.针对 EBV 糖蛋白 gp350/220 免疫显性区新型糖肽表位的多样化 IgG 血清反应:O-糖肽微阵列的诊断潜力。
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本文引用的文献

1
A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates.一种用于O-连接N-乙酰葡糖胺转移酶的高通量检测方法可检测肽底物中的一级序列偏好性。
Bioorg Med Chem Lett. 2007 Jul 15;17(14):3851-4. doi: 10.1016/j.bmcl.2007.05.008. Epub 2007 May 10.
2
Carbohydrate microarrays for assaying galactosyltransferase activity.用于检测半乳糖基转移酶活性的碳水化合物微阵列。
Org Lett. 2007 Apr 26;9(9):1675-8. doi: 10.1021/ol070250l. Epub 2007 Mar 30.
3
Efficient enzymatic glycosylation of peptides and oligosaccharides from GalNAc and UTP.
Chembiochem. 2007 Jan 2;8(1):37-40. doi: 10.1002/cbic.200600369.
4
Identification of common and unique peptide substrate preferences for the UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases T1 and T2 derived from oriented random peptide substrates.从定向随机肽底物中鉴定UDP-N-乙酰半乳糖胺:多肽α-N-乙酰半乳糖胺基转移酶T1和T2常见和独特的肽底物偏好
J Biol Chem. 2006 Oct 27;281(43):32403-16. doi: 10.1074/jbc.M605149200. Epub 2006 Aug 15.
5
Direct and efficient monitoring of glycosyltransferase reactions on gold colloidal nanoparticles by using mass spectrometry.利用质谱法直接高效监测金胶态纳米颗粒上的糖基转移酶反应。
Chemistry. 2006 Aug 25;12(25):6478-85. doi: 10.1002/chem.200501267.
6
Efficient monitoring of enzymatic conjugation reaction by surface-enhanced laser desorption/ionization time of flight mass spectrometry for process optimization.通过表面增强激光解吸/电离飞行时间质谱对酶促共轭反应进行高效监测以优化过程。
Bioconjug Chem. 2006 Mar-Apr;17(2):559-64. doi: 10.1021/bc0502661.
7
Identification of new acceptor specificities of glycosyltransferase R with the aid of substrate microarrays.
Chembiochem. 2006 Feb;7(2):310-20. doi: 10.1002/cbic.200500350.
8
Protein posttranslational modifications: the chemistry of proteome diversifications.蛋白质翻译后修饰:蛋白质组多样化的化学过程
Angew Chem Int Ed Engl. 2005 Dec 1;44(45):7342-72. doi: 10.1002/anie.200501023.
9
Label-free detection of protein-protein interactions on biochips.生物芯片上蛋白质-蛋白质相互作用的无标记检测。
Angew Chem Int Ed Engl. 2005 Aug 26;44(34):5480-3. doi: 10.1002/anie.200501363.
10
The chemistry and biology of mucin-type O-linked glycosylation.粘蛋白型O-连接糖基化的化学与生物学
Bioorg Med Chem. 2005 Sep 1;13(17):5021-34. doi: 10.1016/j.bmc.2005.04.085.

Enzymatic glycosylation of peptide arrays on gold surfaces.

作者信息

Laurent Nicolas, Voglmeir Josef, Wright Adam, Blackburn Jonathan, Pham Nhan T, Wong Stephen C C, Gaskell Simon J, Flitsch Sabine L

机构信息

Manchester Interdisciplinary Biocentre and School of Chemistry, The University of Manchester, 131 Princess Street Manchester M1 7DN, UK.

出版信息

Chembiochem. 2008 Apr 14;9(6):883-7. doi: 10.1002/cbic.200700692.

DOI:10.1002/cbic.200700692
PMID:18330850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2635019/
Abstract
摘要