Munafò Marcus R, Johnstone Elaine C
Department of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK.
Addict Biol. 2008 Sep;13(3-4):435-9. doi: 10.1111/j.1369-1600.2008.00098.x. Epub 2008 Mar 7.
Recently, a variable number of tandem repeats (VNTR) polymorphism in the dopamine D4 receptor (DRD4) gene has been reported to be associated with greater craving and more attention to smoking cues, following a cue-elicited craving procedure. We investigated whether the DRD4 VNTR 7-repeat polymorphism is associated with selective processing of smoking-related stimuli, using a modified Stroop task, and whether smoking status moderates this association. Thirty-one current smokers and 17 ex-smokers attended a single testing session and completed the modified Stroop task. The experimental design included two between-subjects factors of smoking status (current smoker, ex-smoker) and DRD4 genotype (short, long). The DRD4 VNTR polymorphism was associated with selective processing of smoking-related stimuli in ex-smokers but not in current smokers. Our data, therefore, provide partial support for our primary hypothesis and extend on previous work which suggests a role for variation at the DRD4 locus in modulating reactivity to drug-related cues.
最近，有报道称，在一种线索诱发的渴望程序后，多巴胺D4受体（DRD4）基因中的可变数目串联重复序列（VNTR）多态性与更强烈的渴望以及对吸烟线索的更多关注有关。我们使用改良的Stroop任务，研究了DRD4 VNTR 7重复多态性是否与吸烟相关刺激的选择性加工有关，以及吸烟状态是否会调节这种关联。31名当前吸烟者和17名既往吸烟者参加了一次测试，并完成了改良的Stroop任务。实验设计包括吸烟状态（当前吸烟者、既往吸烟者）和DRD4基因型（短、长）这两个组间因素。DRD4 VNTR多态性与既往吸烟者而非当前吸烟者对吸烟相关刺激的选择性加工有关。因此，我们的数据为我们的主要假设提供了部分支持，并扩展了先前的研究工作，这些研究表明DRD4位点的变异在调节对药物相关线索的反应性方面发挥作用。
