Kyle Robert A, Rajkumar S Vincent
Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA.
Blood. 2008 Mar 15;111(6):2962-72. doi: 10.1182/blood-2007-10-078022.
Multiple myeloma is a clonal plasma cell malignancy that accounts for slightly more than 10% of all hematologic cancers. In this paper, we present a historically focused review of the disease, from the description of the first case in 1844 to the present. The evolution of drug therapy and stem-cell transplantation for the treatment of myeloma, as well as the development of new agents, is discussed. We also provide an update on current concepts of diagnosis and therapy, with an emphasis on how treatments have emerged from a historical perspective after certain important discoveries and the results of experimental studies.
多发性骨髓瘤是一种克隆性浆细胞恶性肿瘤，占所有血液系统癌症的比例略高于10%。在本文中，我们对该疾病进行了以历史为重点的综述，涵盖从1844年首例病例的描述至今。文中讨论了骨髓瘤治疗中药物疗法和干细胞移植的演变，以及新药物的研发。我们还提供了当前诊断和治疗概念的最新情况，重点阐述了在某些重要发现和实验研究结果之后，治疗方法是如何从历史角度发展而来的。
